Comparative effects of vasodilator drugs on large and small coronary resistance vessels in the dog

Robert Forman, Edward S. Kirk

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Summary: One of the mechanisms whereby nitroglycerin is considered to reduce myocardial ischaemia and spasm is its preferential reduction of resistance of large compared with small coronary arteries. Accordingly, the action of nitroglycerin on these two resistance beds was compared with newer coronary vasodilator drugs. Following intracoronary administration of boluses of each drug, large and small vessel coronary resistance was measured in 14 dogs by recording the pressure drop across each vascular bed while flow was held constant. The dose of each drug was given to reduce small vessel resistance by 30% (range means 27 to 32%) which peaked at 5 to 10 s and declined to 8 to 18% at 1 min when reduction in large vessel resistance was at its maximum. At 1 min the large vessel resistance was decreased 56±5% by nitroglycerin, 23±5% by nitroprusside, 8±4% by perhexiline, 0±5% by verapamil and increased 8±5% by nifedipine. Nitroprusside reduced the large vessel resistance significantly less than nitroglycerin (P <0.001) for an equivalent reduction in small vessel resistance. Perhexiline, verapamil and nifedipine did not significantly reduce large vessel resistance and the discrepancy between these results and their antianginal and antispasm effect in humans was not apparent from these experiments. However, a suitable model of coronary spasm in the dog following ergonovine injection could not be created.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalCardiovascular Research
Volume14
Issue number10
DOIs
StatePublished - Oct 1980

Fingerprint

Nitroglycerin
Vasodilator Agents
Vessel
Coronary Vessels
Drugs
Perhexiline
Dogs
Spasm
Nitroprusside
Nifedipine
Verapamil
Ergonovine
Pressure drop
Pharmaceutical Preparations
Myocardial Ischemia
Blood Vessels
Pressure
Injections
Resistance
Dog

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Comparative effects of vasodilator drugs on large and small coronary resistance vessels in the dog. / Forman, Robert; Kirk, Edward S.

In: Cardiovascular Research, Vol. 14, No. 10, 10.1980, p. 601-606.

Research output: Contribution to journalArticle

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