Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure

The Captopril-Digoxin Multicenter Research Group

Research output: Contribution to journalArticle

527 Citations (Scopus)

Abstract

This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume259
Issue number4
DOIs
StatePublished - Jan 22 1988
Externally publishedYes

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Digoxin
Captopril
Heart Failure
Placebos
Diuretics
Therapeutics
Ventricular Premature Complexes
Treatment Failure
Hypotension
Hospitalization
Maintenance
Exercise

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure. / The Captopril-Digoxin Multicenter Research Group.

In: JAMA: The Journal of the American Medical Association, Vol. 259, No. 4, 22.01.1988, p. 539-544.

Research output: Contribution to journalArticle

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abstract = "This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41{\%} vs 22{\%}), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4{\%} increase) compared with captopril therapy (1.8{\%} increase) and placebo (0.9{\%} increase). The number of ventricular premature beats decreased 45{\%} in the captopril group and increased 4{\%} in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.",
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