Comparative cardiovascular effects of midazolam and thiopental in healthy patients

P. W. Lebowitz, M. E. Cote, A. L. Daniels, F. M. Ramsey, J. A. Martyn, R. S. Teplick, J. K. Davison

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Midazolam, a water-soluble benzodiazepine that is shorter-acting, more potent, and less irritating to veins than diazepam, has been suggested for use for induction of anesthesia. The cardiovascular effects of an induction-sized dose (0.25 mg/kg) of midazolam in A.S.A. class I or II surgical patients (N = 11) sedated with morphine and N2 O-O2 were compared in a double-blind fashion with a similar group of patients (N = 9) receiving thiopental (4.0 mg/kg). Consistent with earlier studies, patients given thiopental experienced downward trends from base line in mean arterial pressure, stroke volume, cardiac output, and heart rate; mean right atrial pressure increased slightly, whereas systemic vascular resistance did not change. Induction of anesthesia with midazolam was associated with more gradual and less pronounced hemodynamic alteration; the only significant changes from base line were decreases in mean arterial pressure 5 and 10 minutes after injection. When the two groups were compared, no significant differences were found. Midazolam is, then, as acceptable for induction of anesthesia as thiopental from a hemodynamic point of view in A.S.A. class I and II patients.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalUnknown Journal
Issue number9
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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