Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

Sheila L. Macrae, Quanwei Zhang, Christophe Lemetre, Inge Seim, Robert B. Calder, Jan Hoeijmakers, Yousin Suh, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova, Jan Vijg, Zhengdong D. Zhang

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long-lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalAging cell
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • Aging
  • Gene duplication
  • Genome maintenance
  • Longevity
  • Mutation rate

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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  • Cite this

    Macrae, S. L., Zhang, Q., Lemetre, C., Seim, I., Calder, R. B., Hoeijmakers, J., Suh, Y., Gladyshev, V. N., Seluanov, A., Gorbunova, V., Vijg, J., & Zhang, Z. D. (2015). Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging cell, 14(2), 288-291. https://doi.org/10.1111/acel.12314