Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

Sheila L. Macrae, Quanwei Zhang, Christophe Lemetre, Inge Seim, Robert B. Calder, Jan Hoeijmakers, Yousin Suh, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova, Jan Vijg, Zhengdong Zhang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long-lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalAging Cell
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Mole Rats
Maintenance
Genome
Genes
Genomic Instability
Telomere
Human Genome
Mutation Rate
DNA Repair
Nucleotides
Neoplasms

Keywords

  • Aging
  • Gene duplication
  • Genome maintenance
  • Longevity
  • Mutation rate

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. / Macrae, Sheila L.; Zhang, Quanwei; Lemetre, Christophe; Seim, Inge; Calder, Robert B.; Hoeijmakers, Jan; Suh, Yousin; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera; Vijg, Jan; Zhang, Zhengdong.

In: Aging Cell, Vol. 14, No. 2, 01.04.2015, p. 288-291.

Research output: Contribution to journalArticle

Macrae, SL, Zhang, Q, Lemetre, C, Seim, I, Calder, RB, Hoeijmakers, J, Suh, Y, Gladyshev, VN, Seluanov, A, Gorbunova, V, Vijg, J & Zhang, Z 2015, 'Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human', Aging Cell, vol. 14, no. 2, pp. 288-291. https://doi.org/10.1111/acel.12314
Macrae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J et al. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell. 2015 Apr 1;14(2):288-291. https://doi.org/10.1111/acel.12314
Macrae, Sheila L. ; Zhang, Quanwei ; Lemetre, Christophe ; Seim, Inge ; Calder, Robert B. ; Hoeijmakers, Jan ; Suh, Yousin ; Gladyshev, Vadim N. ; Seluanov, Andrei ; Gorbunova, Vera ; Vijg, Jan ; Zhang, Zhengdong. / Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. In: Aging Cell. 2015 ; Vol. 14, No. 2. pp. 288-291.
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