Combinatorial Haplo-deficient tumor suppression in 7q-Deficient myelodysplastic syndrome and acute myeloid leukemia

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Abstract

Heterozygous deletions of chromosome 7 are frequent in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this issue of Cancer Cell, Chen and colleagues identify MLL3 as a novel haplo-insufficient tumor suppressor on 7q that, in combination with NF1 suppression and TP53 deficiency, mediates MDS and AML phenotypes in mouse and human systems.

Original languageEnglish (US)
Pages (from-to)555-557
Number of pages3
JournalCancer Cell
Volume25
Issue number5
DOIs
Publication statusPublished - May 12 2014

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ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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