Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

Marta Feldmesser, Jean Mukherjee, Arturo Casadevall

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Abstract

The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume37
Issue number3
DOIs
Publication statusPublished - Apr 29 1996

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ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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