Colorectal neoplasms: Prospective comparison of thin-section low-dose multi-detector row CT colonography and conventional colonoscopy for detection

Michael Macari, Edmund J. Bini, Xiaonan (Nan) Xue, Andrew Milano, Seth S. Katz, Daniel Resnick, Hersh Chandarana, Glen Krinsky, Klaus Klingenbeck, Christopher H. Marshall, Alec J. Megibow

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

PURPOSE: To prospectively compare thin-section low-dose multi-detector row computed tomographic (CT) colonography with conventional colonoscopy for the detection of colorectal neoplasms. MATERIALS AND METHODS: One hundred five patients underwent CT colonography immediately before colonoscopy. Supine and prone CT colonographic acquisitions to image the region during a 30-second breath hold were performed. CT colonographic images were prospectively interpreted for the presence, location, size, and morphologic features of polyps. The time of image interpretation was noted. Sensitivity, specificity, and positive and negative predictive values of CT colonography were calculated, with 95% Cls, by using colonoscopic findings as the reference standard. The weighted CT dose index was calculated on the basis of measurements in a standard body phantom. Effective dose was calculated by using commercially available software. RESULTS: Median CT data interpretation time was 12 minutes. One hundred thirty-two polyps in 59 patients were identified at colonoscopy; no polyps were detected in 46 patients. Sensitivities for detection of polyps smaller than 5 mm, 6-9 mm, and larger than 10 mm in diameter were 12% (11 of 91 polyps), 70% (19 of 27 polyps), and 93% (13 of 14 polyps), respectively. Estimated overall specificity was 97.7% (515 of 527 imaging results). The total weighted CT dose index for combined supine and prone CT colonography was 11.4 mGy. The effective doses for combined CT colonography were 5.0 mSv and 7.8 mSv for men and women, respectively. CONCLUSION: Low-dose multi-detector row CT colonography has excellent sensitivity and specificity for detection of colorectal neoplasms 10 mm and larger.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalRadiology
Volume224
Issue number2
StatePublished - 2002
Externally publishedYes

Fingerprint

Computed Tomographic Colonography
Colonoscopy
Polyps
Colorectal Neoplasms
Sensitivity and Specificity
Software

Keywords

  • Colon neoplasms
  • Colon neoplasms CT
  • Colon, CT
  • Colonoscopy
  • Computed tomography (CT), comparative studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Colorectal neoplasms : Prospective comparison of thin-section low-dose multi-detector row CT colonography and conventional colonoscopy for detection. / Macari, Michael; Bini, Edmund J.; Xue, Xiaonan (Nan); Milano, Andrew; Katz, Seth S.; Resnick, Daniel; Chandarana, Hersh; Krinsky, Glen; Klingenbeck, Klaus; Marshall, Christopher H.; Megibow, Alec J.

In: Radiology, Vol. 224, No. 2, 2002, p. 383-392.

Research output: Contribution to journalArticle

Macari, M, Bini, EJ, Xue, XN, Milano, A, Katz, SS, Resnick, D, Chandarana, H, Krinsky, G, Klingenbeck, K, Marshall, CH & Megibow, AJ 2002, 'Colorectal neoplasms: Prospective comparison of thin-section low-dose multi-detector row CT colonography and conventional colonoscopy for detection', Radiology, vol. 224, no. 2, pp. 383-392.
Macari, Michael ; Bini, Edmund J. ; Xue, Xiaonan (Nan) ; Milano, Andrew ; Katz, Seth S. ; Resnick, Daniel ; Chandarana, Hersh ; Krinsky, Glen ; Klingenbeck, Klaus ; Marshall, Christopher H. ; Megibow, Alec J. / Colorectal neoplasms : Prospective comparison of thin-section low-dose multi-detector row CT colonography and conventional colonoscopy for detection. In: Radiology. 2002 ; Vol. 224, No. 2. pp. 383-392.
@article{b6136d2ad3bf4258b719ec3244d220b0,
title = "Colorectal neoplasms: Prospective comparison of thin-section low-dose multi-detector row CT colonography and conventional colonoscopy for detection",
abstract = "PURPOSE: To prospectively compare thin-section low-dose multi-detector row computed tomographic (CT) colonography with conventional colonoscopy for the detection of colorectal neoplasms. MATERIALS AND METHODS: One hundred five patients underwent CT colonography immediately before colonoscopy. Supine and prone CT colonographic acquisitions to image the region during a 30-second breath hold were performed. CT colonographic images were prospectively interpreted for the presence, location, size, and morphologic features of polyps. The time of image interpretation was noted. Sensitivity, specificity, and positive and negative predictive values of CT colonography were calculated, with 95{\%} Cls, by using colonoscopic findings as the reference standard. The weighted CT dose index was calculated on the basis of measurements in a standard body phantom. Effective dose was calculated by using commercially available software. RESULTS: Median CT data interpretation time was 12 minutes. One hundred thirty-two polyps in 59 patients were identified at colonoscopy; no polyps were detected in 46 patients. Sensitivities for detection of polyps smaller than 5 mm, 6-9 mm, and larger than 10 mm in diameter were 12{\%} (11 of 91 polyps), 70{\%} (19 of 27 polyps), and 93{\%} (13 of 14 polyps), respectively. Estimated overall specificity was 97.7{\%} (515 of 527 imaging results). The total weighted CT dose index for combined supine and prone CT colonography was 11.4 mGy. The effective doses for combined CT colonography were 5.0 mSv and 7.8 mSv for men and women, respectively. CONCLUSION: Low-dose multi-detector row CT colonography has excellent sensitivity and specificity for detection of colorectal neoplasms 10 mm and larger.",
keywords = "Colon neoplasms, Colon neoplasms CT, Colon, CT, Colonoscopy, Computed tomography (CT), comparative studies",
author = "Michael Macari and Bini, {Edmund J.} and Xue, {Xiaonan (Nan)} and Andrew Milano and Katz, {Seth S.} and Daniel Resnick and Hersh Chandarana and Glen Krinsky and Klaus Klingenbeck and Marshall, {Christopher H.} and Megibow, {Alec J.}",
year = "2002",
language = "English (US)",
volume = "224",
pages = "383--392",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Colorectal neoplasms

T2 - Prospective comparison of thin-section low-dose multi-detector row CT colonography and conventional colonoscopy for detection

AU - Macari, Michael

AU - Bini, Edmund J.

AU - Xue, Xiaonan (Nan)

AU - Milano, Andrew

AU - Katz, Seth S.

AU - Resnick, Daniel

AU - Chandarana, Hersh

AU - Krinsky, Glen

AU - Klingenbeck, Klaus

AU - Marshall, Christopher H.

AU - Megibow, Alec J.

PY - 2002

Y1 - 2002

N2 - PURPOSE: To prospectively compare thin-section low-dose multi-detector row computed tomographic (CT) colonography with conventional colonoscopy for the detection of colorectal neoplasms. MATERIALS AND METHODS: One hundred five patients underwent CT colonography immediately before colonoscopy. Supine and prone CT colonographic acquisitions to image the region during a 30-second breath hold were performed. CT colonographic images were prospectively interpreted for the presence, location, size, and morphologic features of polyps. The time of image interpretation was noted. Sensitivity, specificity, and positive and negative predictive values of CT colonography were calculated, with 95% Cls, by using colonoscopic findings as the reference standard. The weighted CT dose index was calculated on the basis of measurements in a standard body phantom. Effective dose was calculated by using commercially available software. RESULTS: Median CT data interpretation time was 12 minutes. One hundred thirty-two polyps in 59 patients were identified at colonoscopy; no polyps were detected in 46 patients. Sensitivities for detection of polyps smaller than 5 mm, 6-9 mm, and larger than 10 mm in diameter were 12% (11 of 91 polyps), 70% (19 of 27 polyps), and 93% (13 of 14 polyps), respectively. Estimated overall specificity was 97.7% (515 of 527 imaging results). The total weighted CT dose index for combined supine and prone CT colonography was 11.4 mGy. The effective doses for combined CT colonography were 5.0 mSv and 7.8 mSv for men and women, respectively. CONCLUSION: Low-dose multi-detector row CT colonography has excellent sensitivity and specificity for detection of colorectal neoplasms 10 mm and larger.

AB - PURPOSE: To prospectively compare thin-section low-dose multi-detector row computed tomographic (CT) colonography with conventional colonoscopy for the detection of colorectal neoplasms. MATERIALS AND METHODS: One hundred five patients underwent CT colonography immediately before colonoscopy. Supine and prone CT colonographic acquisitions to image the region during a 30-second breath hold were performed. CT colonographic images were prospectively interpreted for the presence, location, size, and morphologic features of polyps. The time of image interpretation was noted. Sensitivity, specificity, and positive and negative predictive values of CT colonography were calculated, with 95% Cls, by using colonoscopic findings as the reference standard. The weighted CT dose index was calculated on the basis of measurements in a standard body phantom. Effective dose was calculated by using commercially available software. RESULTS: Median CT data interpretation time was 12 minutes. One hundred thirty-two polyps in 59 patients were identified at colonoscopy; no polyps were detected in 46 patients. Sensitivities for detection of polyps smaller than 5 mm, 6-9 mm, and larger than 10 mm in diameter were 12% (11 of 91 polyps), 70% (19 of 27 polyps), and 93% (13 of 14 polyps), respectively. Estimated overall specificity was 97.7% (515 of 527 imaging results). The total weighted CT dose index for combined supine and prone CT colonography was 11.4 mGy. The effective doses for combined CT colonography were 5.0 mSv and 7.8 mSv for men and women, respectively. CONCLUSION: Low-dose multi-detector row CT colonography has excellent sensitivity and specificity for detection of colorectal neoplasms 10 mm and larger.

KW - Colon neoplasms

KW - Colon neoplasms CT

KW - Colon, CT

KW - Colonoscopy

KW - Computed tomography (CT), comparative studies

UR - http://www.scopus.com/inward/record.url?scp=0036315281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036315281&partnerID=8YFLogxK

M3 - Article

C2 - 12147833

AN - SCOPUS:0036315281

VL - 224

SP - 383

EP - 392

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -