Colorectal neoplasia

Performance characteristics of CT colonography for detection in 300 patients

Judy Yee, Geetanjali A. Akerkar, Raymond K. Hung, Andreas M. Steinauer-Gebauer, Susan D. Wall, Kenneth R. McQuaid

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine the sensitivity and specificity of computed tomographic (CT) colonography for colorectal polyp and cancer detection by using colonoscopy as the reference standard. MATERIALS AND METHODS: Three hundred patients underwent CT colonography followed by Standard Colonoscopy. Bowel preparation consisted of magnesium citrate and polyethylene glycol. After colonic air insufflation, patients underwent scanning in the supine and prone positions with 3-mm collimation during a single breath hold. The transverse CT images, sagittal and Coronal reformations, and three-dimensional endoluminal images were interpreted by two radiologists independently, and then a consensus reading was performed. CT colonographic findings were correlated with standard colonoscopic and histologic findings. RESULTS: The overall sensitivity and specificity of CT colonography for polyp detection were 90.1% (164 of 182) and 72.0% (85 of 118), respectively. By using direct polyp matching, the overall sensitivity was 69.7% (365 of 524). The sensitivity was 90% (74 of 82) for the detection of polyps 10 mm or larger, 80.1% (113 of 141) for polyps 5.0-9.9 mm, and 59.1% (178 of 301) for polyps smaller than 5 mm. The sensitivity was 94% (64 of 68) for the detection of adenomas 10 mm or larger, 82% (72 of 88) for adenomas 5.0-9.9 mm, and 66.9% (95 of 142) for adenomas smaller than 5 mm. CT colonography was used to identify all eight carcinomas. CONCLUSION: CT colonography has excellent sensitivity for the detection of clinically important colorectal polyps and cancer.

Original languageEnglish (US)
Pages (from-to)685-692
Number of pages8
JournalRadiology
Volume219
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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Computed Tomographic Colonography
Polyps
Neoplasms
Adenoma
Colonoscopy
Colorectal Neoplasms
Sensitivity and Specificity
Prone Position
Insufflation
Three-Dimensional Imaging
Supine Position
Reading
Air
Carcinoma

Keywords

  • Colon neoplasms, 75.311
  • Colon, CT, 75.12115, 75.12117, 75.12119
  • Computed tomography (CT), image processing, 75.12117, 75.12119
  • Computed tomography (CT), three-dimensional, 75.12117, 75.12119
  • Images, analysis, 75.12115, 75.12117, 75.12119

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Yee, J., Akerkar, G. A., Hung, R. K., Steinauer-Gebauer, A. M., Wall, S. D., & McQuaid, K. R. (2001). Colorectal neoplasia: Performance characteristics of CT colonography for detection in 300 patients. Radiology, 219(3), 685-692. https://doi.org/10.1148/radiology.219.3.r01jn40685

Colorectal neoplasia : Performance characteristics of CT colonography for detection in 300 patients. / Yee, Judy; Akerkar, Geetanjali A.; Hung, Raymond K.; Steinauer-Gebauer, Andreas M.; Wall, Susan D.; McQuaid, Kenneth R.

In: Radiology, Vol. 219, No. 3, 01.01.2001, p. 685-692.

Research output: Contribution to journalArticle

Yee, J, Akerkar, GA, Hung, RK, Steinauer-Gebauer, AM, Wall, SD & McQuaid, KR 2001, 'Colorectal neoplasia: Performance characteristics of CT colonography for detection in 300 patients', Radiology, vol. 219, no. 3, pp. 685-692. https://doi.org/10.1148/radiology.219.3.r01jn40685
Yee, Judy ; Akerkar, Geetanjali A. ; Hung, Raymond K. ; Steinauer-Gebauer, Andreas M. ; Wall, Susan D. ; McQuaid, Kenneth R. / Colorectal neoplasia : Performance characteristics of CT colonography for detection in 300 patients. In: Radiology. 2001 ; Vol. 219, No. 3. pp. 685-692.
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abstract = "PURPOSE: To determine the sensitivity and specificity of computed tomographic (CT) colonography for colorectal polyp and cancer detection by using colonoscopy as the reference standard. MATERIALS AND METHODS: Three hundred patients underwent CT colonography followed by Standard Colonoscopy. Bowel preparation consisted of magnesium citrate and polyethylene glycol. After colonic air insufflation, patients underwent scanning in the supine and prone positions with 3-mm collimation during a single breath hold. The transverse CT images, sagittal and Coronal reformations, and three-dimensional endoluminal images were interpreted by two radiologists independently, and then a consensus reading was performed. CT colonographic findings were correlated with standard colonoscopic and histologic findings. RESULTS: The overall sensitivity and specificity of CT colonography for polyp detection were 90.1{\%} (164 of 182) and 72.0{\%} (85 of 118), respectively. By using direct polyp matching, the overall sensitivity was 69.7{\%} (365 of 524). The sensitivity was 90{\%} (74 of 82) for the detection of polyps 10 mm or larger, 80.1{\%} (113 of 141) for polyps 5.0-9.9 mm, and 59.1{\%} (178 of 301) for polyps smaller than 5 mm. The sensitivity was 94{\%} (64 of 68) for the detection of adenomas 10 mm or larger, 82{\%} (72 of 88) for adenomas 5.0-9.9 mm, and 66.9{\%} (95 of 142) for adenomas smaller than 5 mm. CT colonography was used to identify all eight carcinomas. CONCLUSION: CT colonography has excellent sensitivity for the detection of clinically important colorectal polyps and cancer.",
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KW - Images, analysis, 75.12115, 75.12117, 75.12119

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