Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: A clinical review and update

David T. Rubin, Marcia R. Cruz-Correa, Christoph Gasche, Jeremy R. Jass, Gary R. Lichtenstein, Elizabeth A. Montgomery, Robert H. Riddell, Matthew D. Rutter, Thomas A. Ullman, Fernando S. Velayos, Steven Itzkowitz

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

A roundtable consensus meeting was held to consolidate current knowledge on the etiology of colorectal cancer in patients with inflammatory bowel disease and to review current strategies, both diagnostic and preventive, specifically addressing the role of 5-aminosalicylic acid. Specific topics that were addressed included: the epidemiology of colorectal cancer, including an assessment of risk factors and the impact of colonoscopy on colorectal cancer incidence and mortality; the origin and evolution of dysplasia nomenclature and the natural history of dysplasia; review of the experience of St. Mark's Hospital (London) as gleaned from its surveillance database; mechanisms by which 5-aminosalicylic acid is thought to exert a chemopreventive effect; the potential future role of 5-aminosalicylic acid in chemopreventive strategies; chemoprevention in familial adenomatous polyposis; and other future research directions. This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalInflammatory bowel diseases
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • 5-aminosalicylic acid
  • Chemoprevention
  • Colorectal cancer
  • Crohn's disease
  • Dysplasia
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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    Rubin, D. T., Cruz-Correa, M. R., Gasche, C., Jass, J. R., Lichtenstein, G. R., Montgomery, E. A., Riddell, R. H., Rutter, M. D., Ullman, T. A., Velayos, F. S., & Itzkowitz, S. (2008). Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: A clinical review and update. Inflammatory bowel diseases, 14(2), 265-274. https://doi.org/10.1002/ibd.20297