Colorectal cancer incidence in asian populations in california: Effect of nativity and neighborhood-level factors

Uri Ladabaum, Christina A. Clarke, David J. Press, Ajitha Mannalithara, Parvathi A. Myer, Iona Cheng, Scarlett Lin Gomez

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES:Heritable and environmental factors may contribute to differences in colorectal cancer (CRC) incidence across populations. We capitalized on the resources of the California Cancer Registry (CCR) and California's diverse Asian population to perform a cohort study exploring the relationships between CRC incidence, nativity, and neighborhood-level factors across Asian subgroups.METHODS:We identified CRC cases in the CCR from 1990 to 2004 and calculated age-adjusted CRC incidence rates for non-Hispanic Whites and US-born vs. foreign-born Asian ethnic subgroups, stratified by neighborhood socioeconomic status (SES) and "ethnic enclave." Trends were studied with joinpoint analysis.RESULTS:CRC incidence was lowest among foreign-born South Asians (22.0/100,000; 95% confidence interval (CI): 19.7-24.5/100,000) and highest among foreign-born Japanese (74.6/100,000; 95% CI: 70.1-79.2/100,000). Women in all Asian subgroups except Japanese, and men in all Asian subgroups except Japanese and US-born Chinese, had lower CRC incidence than non-Hispanic Whites. Among Chinese men and Filipino women and men, CRC incidence was lower among foreign-born than US-born persons; the opposite was observed for Japanese women and men. Among non-Hispanic Whites, but not most Asian subgroups, CRC incidence decreased over time. CRC incidence was inversely associated with neighborhood SES among non-Hispanic Whites, and level of ethnic enclave among Asians.CONCLUSIONS:CRC incidence rates differ substantially across Asian subgroups in California. The significant associations between CRC incidence and nativity and residence in an ethnic enclave suggest a substantial effect of acquired environmental factors. The absence of declines in CRC incidence rates among most Asians during our study period may point to disparities in screening compared with Whites.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalAmerican Journal of Gastroenterology
Volume109
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

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Colorectal Neoplasms
Incidence
Population
Social Class
Registries
Confidence Intervals
Neoplasms
Cohort Studies

ASJC Scopus subject areas

  • Gastroenterology

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Colorectal cancer incidence in asian populations in california : Effect of nativity and neighborhood-level factors. / Ladabaum, Uri; Clarke, Christina A.; Press, David J.; Mannalithara, Ajitha; Myer, Parvathi A.; Cheng, Iona; Gomez, Scarlett Lin.

In: American Journal of Gastroenterology, Vol. 109, No. 4, 2014, p. 579-588.

Research output: Contribution to journalArticle

Ladabaum, Uri ; Clarke, Christina A. ; Press, David J. ; Mannalithara, Ajitha ; Myer, Parvathi A. ; Cheng, Iona ; Gomez, Scarlett Lin. / Colorectal cancer incidence in asian populations in california : Effect of nativity and neighborhood-level factors. In: American Journal of Gastroenterology. 2014 ; Vol. 109, No. 4. pp. 579-588.
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title = "Colorectal cancer incidence in asian populations in california: Effect of nativity and neighborhood-level factors",
abstract = "OBJECTIVES:Heritable and environmental factors may contribute to differences in colorectal cancer (CRC) incidence across populations. We capitalized on the resources of the California Cancer Registry (CCR) and California's diverse Asian population to perform a cohort study exploring the relationships between CRC incidence, nativity, and neighborhood-level factors across Asian subgroups.METHODS:We identified CRC cases in the CCR from 1990 to 2004 and calculated age-adjusted CRC incidence rates for non-Hispanic Whites and US-born vs. foreign-born Asian ethnic subgroups, stratified by neighborhood socioeconomic status (SES) and {"}ethnic enclave.{"} Trends were studied with joinpoint analysis.RESULTS:CRC incidence was lowest among foreign-born South Asians (22.0/100,000; 95{\%} confidence interval (CI): 19.7-24.5/100,000) and highest among foreign-born Japanese (74.6/100,000; 95{\%} CI: 70.1-79.2/100,000). Women in all Asian subgroups except Japanese, and men in all Asian subgroups except Japanese and US-born Chinese, had lower CRC incidence than non-Hispanic Whites. Among Chinese men and Filipino women and men, CRC incidence was lower among foreign-born than US-born persons; the opposite was observed for Japanese women and men. Among non-Hispanic Whites, but not most Asian subgroups, CRC incidence decreased over time. CRC incidence was inversely associated with neighborhood SES among non-Hispanic Whites, and level of ethnic enclave among Asians.CONCLUSIONS:CRC incidence rates differ substantially across Asian subgroups in California. The significant associations between CRC incidence and nativity and residence in an ethnic enclave suggest a substantial effect of acquired environmental factors. The absence of declines in CRC incidence rates among most Asians during our study period may point to disparities in screening compared with Whites.",
author = "Uri Ladabaum and Clarke, {Christina A.} and Press, {David J.} and Ajitha Mannalithara and Myer, {Parvathi A.} and Iona Cheng and Gomez, {Scarlett Lin}",
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T1 - Colorectal cancer incidence in asian populations in california

T2 - Effect of nativity and neighborhood-level factors

AU - Ladabaum, Uri

AU - Clarke, Christina A.

AU - Press, David J.

AU - Mannalithara, Ajitha

AU - Myer, Parvathi A.

AU - Cheng, Iona

AU - Gomez, Scarlett Lin

PY - 2014

Y1 - 2014

N2 - OBJECTIVES:Heritable and environmental factors may contribute to differences in colorectal cancer (CRC) incidence across populations. We capitalized on the resources of the California Cancer Registry (CCR) and California's diverse Asian population to perform a cohort study exploring the relationships between CRC incidence, nativity, and neighborhood-level factors across Asian subgroups.METHODS:We identified CRC cases in the CCR from 1990 to 2004 and calculated age-adjusted CRC incidence rates for non-Hispanic Whites and US-born vs. foreign-born Asian ethnic subgroups, stratified by neighborhood socioeconomic status (SES) and "ethnic enclave." Trends were studied with joinpoint analysis.RESULTS:CRC incidence was lowest among foreign-born South Asians (22.0/100,000; 95% confidence interval (CI): 19.7-24.5/100,000) and highest among foreign-born Japanese (74.6/100,000; 95% CI: 70.1-79.2/100,000). Women in all Asian subgroups except Japanese, and men in all Asian subgroups except Japanese and US-born Chinese, had lower CRC incidence than non-Hispanic Whites. Among Chinese men and Filipino women and men, CRC incidence was lower among foreign-born than US-born persons; the opposite was observed for Japanese women and men. Among non-Hispanic Whites, but not most Asian subgroups, CRC incidence decreased over time. CRC incidence was inversely associated with neighborhood SES among non-Hispanic Whites, and level of ethnic enclave among Asians.CONCLUSIONS:CRC incidence rates differ substantially across Asian subgroups in California. The significant associations between CRC incidence and nativity and residence in an ethnic enclave suggest a substantial effect of acquired environmental factors. The absence of declines in CRC incidence rates among most Asians during our study period may point to disparities in screening compared with Whites.

AB - OBJECTIVES:Heritable and environmental factors may contribute to differences in colorectal cancer (CRC) incidence across populations. We capitalized on the resources of the California Cancer Registry (CCR) and California's diverse Asian population to perform a cohort study exploring the relationships between CRC incidence, nativity, and neighborhood-level factors across Asian subgroups.METHODS:We identified CRC cases in the CCR from 1990 to 2004 and calculated age-adjusted CRC incidence rates for non-Hispanic Whites and US-born vs. foreign-born Asian ethnic subgroups, stratified by neighborhood socioeconomic status (SES) and "ethnic enclave." Trends were studied with joinpoint analysis.RESULTS:CRC incidence was lowest among foreign-born South Asians (22.0/100,000; 95% confidence interval (CI): 19.7-24.5/100,000) and highest among foreign-born Japanese (74.6/100,000; 95% CI: 70.1-79.2/100,000). Women in all Asian subgroups except Japanese, and men in all Asian subgroups except Japanese and US-born Chinese, had lower CRC incidence than non-Hispanic Whites. Among Chinese men and Filipino women and men, CRC incidence was lower among foreign-born than US-born persons; the opposite was observed for Japanese women and men. Among non-Hispanic Whites, but not most Asian subgroups, CRC incidence decreased over time. CRC incidence was inversely associated with neighborhood SES among non-Hispanic Whites, and level of ethnic enclave among Asians.CONCLUSIONS:CRC incidence rates differ substantially across Asian subgroups in California. The significant associations between CRC incidence and nativity and residence in an ethnic enclave suggest a substantial effect of acquired environmental factors. The absence of declines in CRC incidence rates among most Asians during our study period may point to disparities in screening compared with Whites.

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