Colorectal cancer in mice genetically deficient in the mucin Muc2

Anna Velcich, Wan Cai Yang, Joerg Heyer, Alessandra Fragale, Courtney Nicholas, Stephanie Viani, Raju Kucherlapati, Martin Lipkin, Kan Yang, Leonard Augenlicht

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Abstract

The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal31 cancer.

Original languageEnglish (US)
Pages (from-to)1726-1729
Number of pages4
JournalScience
Volume295
Issue number5560
DOIs
StatePublished - Mar 1 2002

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Velcich, A., Yang, W. C., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002). Colorectal cancer in mice genetically deficient in the mucin Muc2. Science, 295(5560), 1726-1729. https://doi.org/10.1126/science.1069094