Color M-mode doppler flow propagation velocity is a relatively preload- independent index of left ventricular filling

M. J. Garcia, R. T. Palac, D. J. Malenka, P. Terrell, J. F. Plehn

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Standard Doppler indexes of transmitral filling vary in response to alterations in left ventricular (LV) relaxation or preload. To determine whether color M-mode Doppler flow propagation velocity (v(p)), a new index of LV relaxation, is affected by preload, we obtained LV volumes, standard Doppler filling indexes, and V(p) in 20 patients at baseline, during Trendelenburg's position, inverse Trendelenburg's position, and after inhalation of amyl nitrite. LV end-diastolic volume decreased from 111 ± 41 mL at baseline and 116 ± 43 mL during Trendelenburg's position, to 104 ± 40 during inverse Trendelenburg's maneuver and 92 ± 33 mL after inhalation of amyl nitrite (P < .0001). Peak early firing velocity decreased from 79 ± 19 cm/s and 90 ± 20 cm/s to 73 ± 22 cm/s and 64 ± 20 cm/s, respectively (P < 0.0001). In contrast, no significant changes were found in V(p) (48 ± 24 and 50 ± 26 cm/s vs 48 ± 25 and 48 ± 25 cm/s). We conclude that V(p) is not affected significantly by preload. Thus V(p) may provide a more reliable and independent assessment of LV relaxation.

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalJournal of the American Society of Echocardiography
Issue number2
Publication statusPublished - Jan 1 1999
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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