Colony stimulating factor-1 expression is developmentally regulated in the mouse

Philip Roth, E. Richard Stanley

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF-1 plays a role in the perinatal development of these cells, CSF-1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF-1 concentrations rose in liver, kidney, and lung, declined in brain and serum, and did not change in intestine and heart. Concurrently, fetal/neonatal CSF-1 concentrations were higher in liver, kidney, and serum and lower in lung, brain, intestine, and heart than maternal tissue/serum concentrations, which showed no correlations with gestational or post-partum stage. CSF-1 mRNA was detected in all tissues examined and its expression increased ill lung and heart and decreased in brain with increasing fetal/neonatal age. The developmental regulation of mouse CSF-1 expression appears to be important for mononuclear phagocyte development during this period.

Original languageEnglish (US)
Pages (from-to)817-823
Number of pages7
JournalJournal of Leukocyte Biology
Volume59
Issue number6
DOIs
StatePublished - Jun 1996

Keywords

  • Development
  • Growth factor
  • Macrophage
  • Mononuclear phagocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Fingerprint Dive into the research topics of 'Colony stimulating factor-1 expression is developmentally regulated in the mouse'. Together they form a unique fingerprint.

  • Cite this