Colony stimulating factor-1 expression in human glioma

Ron L. Alterman, E. Richard Stanley

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Colony stimulating factor 1 (CSF-1) is a functionally versatile, circulating homodimeric growth factor that stimulates the survival, proliferation, and differentiation of mononuclear phagocytic cells, the differentiation of osteoclast progenitor cells and that regulates cells of the female reproductive tract. CSF-1 is also expressed in the central nervous system where it may regulate the differentiation and activation of microglia. The diverse forms of CSF-1 are all encoded by a single gene. Alternative posttranscriptional splicing and posttranslational cleavage determines whether CSF-1 will be produced as a secreted proteoglycan, secreted glycoprotein, or as a cell-surface glycoprotein that may be involved in cell-cell interactions. CSF-1 is expressed in glioblastoma cell-lines, normal human astrocytes, and in operative specimens of human glioma. The CSF-1 receptor, encoded by the c-fms proto-oncogene, is also expressed in human gliomas. We conclude that coexpression of CSF-1 and its receptor in some human gliomas hints at a possible autocrine or paracrine growth stimulatory role for CSF-1; however, its function in the mammalian CNS remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)177-188
Number of pages12
JournalMolecular and Chemical Neuropathology
Volume21
Issue number2-3
DOIs
StatePublished - Feb 1994

Fingerprint

Macrophage Colony-Stimulating Factor
Glioma
fms Genes
Colony-Stimulating Factor Receptors
Membrane Glycoproteins
Alternative Splicing
Microglia
Osteoclasts
Proteoglycans
Glioblastoma
Phagocytes
Cell Communication
Astrocytes
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Glycoproteins
Stem Cells
Central Nervous System
Cell Line
Survival

Keywords

  • astrocytes
  • brain tumors
  • c-fms
  • CSF-1
  • glioblastoma
  • glycoprotein
  • growth factor
  • microglia
  • proteoglycan

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Molecular Biology

Cite this

Colony stimulating factor-1 expression in human glioma. / Alterman, Ron L.; Stanley, E. Richard.

In: Molecular and Chemical Neuropathology, Vol. 21, No. 2-3, 02.1994, p. 177-188.

Research output: Contribution to journalArticle

Alterman, Ron L. ; Stanley, E. Richard. / Colony stimulating factor-1 expression in human glioma. In: Molecular and Chemical Neuropathology. 1994 ; Vol. 21, No. 2-3. pp. 177-188.
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