Colon ischemia: Recent insights and advances

Paul Feuerstadt, Lawrence J. Brandt

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Ischemic colitis is the most common manifestation of ischemic injury to the gastrointestinal tract, and the variety of defined causes is increasing. Local hypoperfusion and reperfusion injury are both thought to contribute to the disease process, which manifests with a wide spectrum of injury including reversible colopathy (subepithelial hemorrhage and edema), transient colitis, chronic colitis, stricture, gangrene, and fulminant universal colitis. The distribution is typically segmental. Older studies showed that any portion of the colon can be involved; recently, it was established that the site of involvement and prognosis can be correlated. In particular, isolated involvement of the right side of the colon was shown to have a different presentation and worse outcome than ischemic colitis involving other segments. Diagnosis is usually made clinically and supported by radiologic imaging and colonoscopic evaluation. Most patients respond to conservative supportive therapy, although some with severe disease require surgical intervention.

Original languageEnglish (US)
Pages (from-to)383-390
Number of pages8
JournalCurrent gastroenterology reports
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2010

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Keywords

  • Colon ischemia
  • Intestinal blood flow
  • Ischemic colitis

ASJC Scopus subject areas

  • Gastroenterology

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