Collisional activation decomposition of actinomycins using tandem mass spectrometry

J. Roboz, E. Nieves, J. F. Holland, M. McCamish, C. Smith

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The collisional activation (xenon) decomposition of actinomycin V, dactinomycin, 7‐nitrodactinomycin, 7‐aminodactinomycin, and a mixture of dactinomycin, actinomycin C1 and actinomycin C2 was studied using a triple‐quadrupole mass spectrometer with fast atom bombardment (xenon) ionization. Fragmentation pathways of the structurally significant ions were rationalized by assuming an initial McLafferty rearrangement at the ester linkage between the methylvaline and the threonine of both rings to form linear pentapeptides, followed by fragmentation in either pentapeptide yielding typical sequence ions and sequence cleavages from both rings.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalBiological Mass Spectrometry
Volume16
Issue number1-12
DOIs
StatePublished - Oct 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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