Collecting-duct carcinoma of the kidney with prominent signet ring cell features

M. Li, M. A. Vuolo, Karen M. Weidenheim, L. S. Minsky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We report a case in a 74-year-old woman of collecting-duct carcinoma of the kidney with prominent signet ring cell features. Grossly, the tumor measured 5.5 cm in greatest dimension, occupied the entire upper pole of the kidney, and was well circumscribed. Microscopically, it displayed a predominant tubulopapillary pattern of growth with a hyalinizing stroma. The tumor tubules were lined by a single layer of cells with large, pleomorphic nuclei, some of which had a hobnail appearance. Large intracytoplasmic vacuoles with compression of nuclei (signet ring cells) were present throughout the tumor. Alcian blue, mucicarmine, and periodic acid-Schiff stains failed to identify intracellular mucin or glycogen in the signet ring cells. Enlarged cells with intracytoplasmic vacuoles were also noted in the adjacent collecting ducts. The tumor cells were immunohistochemically positive for cytokeratin including cytokeratin 7, CAM 5.2, AE1/3, and 34βE12, vimentin, peanut lectin agglutinin, and Ulex europaeus agglutinin. Electron microscopy revealed that the intracytoplasmic vacuoles were due to intracellular edema. To the best of our knowledge, this is the first reported case of renal collecting-duct carcinoma with prominent signet ring cell features.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalModern Pathology
Volume14
Issue number6
DOIs
StatePublished - 2001

Fingerprint

Renal Cell Carcinoma
Vacuoles
Peanut Agglutinin
Neoplasms
Ulex
Keratin-7
Alcian Blue
Periodic Acid
Agglutinins
Vimentin
Mucins
Keratins
Glycogen
Edema
Electron Microscopy
Coloring Agents
Kidney
Growth

Keywords

  • Collecting-duct carcinoma
  • Intracellular edema
  • Kidney
  • Signet ring cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Collecting-duct carcinoma of the kidney with prominent signet ring cell features. / Li, M.; Vuolo, M. A.; Weidenheim, Karen M.; Minsky, L. S.

In: Modern Pathology, Vol. 14, No. 6, 2001, p. 623-628.

Research output: Contribution to journalArticle

Li, M. ; Vuolo, M. A. ; Weidenheim, Karen M. ; Minsky, L. S. / Collecting-duct carcinoma of the kidney with prominent signet ring cell features. In: Modern Pathology. 2001 ; Vol. 14, No. 6. pp. 623-628.
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