Colchicine therapy of the renal amyloidosis of ulcerative colitis

Samuel Meyers, Henry D. Janowitz, Vivek V. Gumaste, Ruth G. Abramson, Laurence J. Berman, V. S. Venkataseshan, Steven H. Dickman

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.

Original languageEnglish (US)
Pages (from-to)1503-1507
Number of pages5
JournalGastroenterology
Volume94
Issue number6
StatePublished - 1988
Externally publishedYes

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Colchicine
Amyloidosis
Ulcerative Colitis
Kidney
Urine
Nephrotic Syndrome
Therapeutics
Proteinuria
Amyloid
Proteins

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Meyers, S., Janowitz, H. D., Gumaste, V. V., Abramson, R. G., Berman, L. J., Venkataseshan, V. S., & Dickman, S. H. (1988). Colchicine therapy of the renal amyloidosis of ulcerative colitis. Gastroenterology, 94(6), 1503-1507.

Colchicine therapy of the renal amyloidosis of ulcerative colitis. / Meyers, Samuel; Janowitz, Henry D.; Gumaste, Vivek V.; Abramson, Ruth G.; Berman, Laurence J.; Venkataseshan, V. S.; Dickman, Steven H.

In: Gastroenterology, Vol. 94, No. 6, 1988, p. 1503-1507.

Research output: Contribution to journalArticle

Meyers, S, Janowitz, HD, Gumaste, VV, Abramson, RG, Berman, LJ, Venkataseshan, VS & Dickman, SH 1988, 'Colchicine therapy of the renal amyloidosis of ulcerative colitis', Gastroenterology, vol. 94, no. 6, pp. 1503-1507.
Meyers S, Janowitz HD, Gumaste VV, Abramson RG, Berman LJ, Venkataseshan VS et al. Colchicine therapy of the renal amyloidosis of ulcerative colitis. Gastroenterology. 1988;94(6):1503-1507.
Meyers, Samuel ; Janowitz, Henry D. ; Gumaste, Vivek V. ; Abramson, Ruth G. ; Berman, Laurence J. ; Venkataseshan, V. S. ; Dickman, Steven H. / Colchicine therapy of the renal amyloidosis of ulcerative colitis. In: Gastroenterology. 1988 ; Vol. 94, No. 6. pp. 1503-1507.
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