Colchicine therapy of the renal amyloidosis of ulcerative colitis

Samuel Meyers, Henry D. Janowitz, Vivek V. Gumaste, Ruth G. Abramson, Laurence J. Berman, V. S. Venkataseshan, Steven H. Dickman

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Abstract

Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.

Original languageEnglish (US)
Pages (from-to)1503-1507
Number of pages5
JournalGastroenterology
Volume94
Issue number6
DOIs
StatePublished - Jun 1988

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Meyers, S., Janowitz, H. D., Gumaste, V. V., Abramson, R. G., Berman, L. J., Venkataseshan, V. S., & Dickman, S. H. (1988). Colchicine therapy of the renal amyloidosis of ulcerative colitis. Gastroenterology, 94(6), 1503-1507. https://doi.org/10.1016/0016-5085(88)90692-0