CogState computerized memory tests in patients with brain metastases

Secondary endpoint results of NRG oncology RTOG 0933

Chip Caine, Snehal Deshmukh, Vinai Gondi, Minesh Mehta, Wolfgang A. Tome, Benjamin W. Corn, Andrew Kanner, Howard Rowley, Vijayananda Kundapur, Albert Denittis, Jeffrey Noah Greenspoon, Andre A. Konski, Glenn S. Bauman, Adam Raben, Wenyin Shi, Merideth Wendland, Lisa Kachnic

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre-and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning Test (OCLT), at baseline, 2 and 4 months. Tests’ completion rates were 52–53% at 2 months and 34–42% at 4 months. All baseline correlations between HVLT-R and CogState tests were significant (p B 0.003). At baseline, both CogState tests and one component of HVLT-R differentiated those who were alive at 6 months and those who had died (p B 0.01). At 4 months, mean relative decline was 7.0% for HVLT-R Delayed Recall and 18.0% for ISLT Delayed Recall. OCLT showed an 8.0% increase. A reliable change index found no significant changes from baseline to 2 and 4 months for ISLT Delayed Recall (z =-0.40, p = 0.34; z =-0.68, p = 0.25) or OCLT (z = 0.15, p = 0.56; z = 0.41, p = 0.66). Study findings support the possibility that hippocampal avoidance may be associated with preservation of memory test performance, and that these computerized tests also may be useful and valid memory assessments in multi-institution adult brain tumor trials.

Original languageEnglish (US)
Pages (from-to)327-336
Number of pages10
JournalJournal of Neuro-Oncology
Volume126
Issue number2
DOIs
StatePublished - 2016

Fingerprint

Verbal Learning
Neoplasm Metastasis
Radiotherapy
Brain
Learning
Brain Neoplasms
Stem Cells
Clinical Trials

Keywords

  • HVLT-R
  • ISLT
  • Neurocognitive
  • NRG Oncology RTOG 0933
  • OCLT

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

CogState computerized memory tests in patients with brain metastases : Secondary endpoint results of NRG oncology RTOG 0933. / Caine, Chip; Deshmukh, Snehal; Gondi, Vinai; Mehta, Minesh; Tome, Wolfgang A.; Corn, Benjamin W.; Kanner, Andrew; Rowley, Howard; Kundapur, Vijayananda; Denittis, Albert; Greenspoon, Jeffrey Noah; Konski, Andre A.; Bauman, Glenn S.; Raben, Adam; Shi, Wenyin; Wendland, Merideth; Kachnic, Lisa.

In: Journal of Neuro-Oncology, Vol. 126, No. 2, 2016, p. 327-336.

Research output: Contribution to journalArticle

Caine, C, Deshmukh, S, Gondi, V, Mehta, M, Tome, WA, Corn, BW, Kanner, A, Rowley, H, Kundapur, V, Denittis, A, Greenspoon, JN, Konski, AA, Bauman, GS, Raben, A, Shi, W, Wendland, M & Kachnic, L 2016, 'CogState computerized memory tests in patients with brain metastases: Secondary endpoint results of NRG oncology RTOG 0933', Journal of Neuro-Oncology, vol. 126, no. 2, pp. 327-336. https://doi.org/10.1007/s11060-015-1971-2
Caine, Chip ; Deshmukh, Snehal ; Gondi, Vinai ; Mehta, Minesh ; Tome, Wolfgang A. ; Corn, Benjamin W. ; Kanner, Andrew ; Rowley, Howard ; Kundapur, Vijayananda ; Denittis, Albert ; Greenspoon, Jeffrey Noah ; Konski, Andre A. ; Bauman, Glenn S. ; Raben, Adam ; Shi, Wenyin ; Wendland, Merideth ; Kachnic, Lisa. / CogState computerized memory tests in patients with brain metastases : Secondary endpoint results of NRG oncology RTOG 0933. In: Journal of Neuro-Oncology. 2016 ; Vol. 126, No. 2. pp. 327-336.
@article{ee4f6d27b22b4219a967b37a710ba824,
title = "CogState computerized memory tests in patients with brain metastases: Secondary endpoint results of NRG oncology RTOG 0933",
abstract = "Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre-and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning Test (OCLT), at baseline, 2 and 4 months. Tests’ completion rates were 52–53{\%} at 2 months and 34–42{\%} at 4 months. All baseline correlations between HVLT-R and CogState tests were significant (p B 0.003). At baseline, both CogState tests and one component of HVLT-R differentiated those who were alive at 6 months and those who had died (p B 0.01). At 4 months, mean relative decline was 7.0{\%} for HVLT-R Delayed Recall and 18.0{\%} for ISLT Delayed Recall. OCLT showed an 8.0{\%} increase. A reliable change index found no significant changes from baseline to 2 and 4 months for ISLT Delayed Recall (z =-0.40, p = 0.34; z =-0.68, p = 0.25) or OCLT (z = 0.15, p = 0.56; z = 0.41, p = 0.66). Study findings support the possibility that hippocampal avoidance may be associated with preservation of memory test performance, and that these computerized tests also may be useful and valid memory assessments in multi-institution adult brain tumor trials.",
keywords = "HVLT-R, ISLT, Neurocognitive, NRG Oncology RTOG 0933, OCLT",
author = "Chip Caine and Snehal Deshmukh and Vinai Gondi and Minesh Mehta and Tome, {Wolfgang A.} and Corn, {Benjamin W.} and Andrew Kanner and Howard Rowley and Vijayananda Kundapur and Albert Denittis and Greenspoon, {Jeffrey Noah} and Konski, {Andre A.} and Bauman, {Glenn S.} and Adam Raben and Wenyin Shi and Merideth Wendland and Lisa Kachnic",
year = "2016",
doi = "10.1007/s11060-015-1971-2",
language = "English (US)",
volume = "126",
pages = "327--336",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - CogState computerized memory tests in patients with brain metastases

T2 - Secondary endpoint results of NRG oncology RTOG 0933

AU - Caine, Chip

AU - Deshmukh, Snehal

AU - Gondi, Vinai

AU - Mehta, Minesh

AU - Tome, Wolfgang A.

AU - Corn, Benjamin W.

AU - Kanner, Andrew

AU - Rowley, Howard

AU - Kundapur, Vijayananda

AU - Denittis, Albert

AU - Greenspoon, Jeffrey Noah

AU - Konski, Andre A.

AU - Bauman, Glenn S.

AU - Raben, Adam

AU - Shi, Wenyin

AU - Wendland, Merideth

AU - Kachnic, Lisa

PY - 2016

Y1 - 2016

N2 - Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre-and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning Test (OCLT), at baseline, 2 and 4 months. Tests’ completion rates were 52–53% at 2 months and 34–42% at 4 months. All baseline correlations between HVLT-R and CogState tests were significant (p B 0.003). At baseline, both CogState tests and one component of HVLT-R differentiated those who were alive at 6 months and those who had died (p B 0.01). At 4 months, mean relative decline was 7.0% for HVLT-R Delayed Recall and 18.0% for ISLT Delayed Recall. OCLT showed an 8.0% increase. A reliable change index found no significant changes from baseline to 2 and 4 months for ISLT Delayed Recall (z =-0.40, p = 0.34; z =-0.68, p = 0.25) or OCLT (z = 0.15, p = 0.56; z = 0.41, p = 0.66). Study findings support the possibility that hippocampal avoidance may be associated with preservation of memory test performance, and that these computerized tests also may be useful and valid memory assessments in multi-institution adult brain tumor trials.

AB - Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre-and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning Test (OCLT), at baseline, 2 and 4 months. Tests’ completion rates were 52–53% at 2 months and 34–42% at 4 months. All baseline correlations between HVLT-R and CogState tests were significant (p B 0.003). At baseline, both CogState tests and one component of HVLT-R differentiated those who were alive at 6 months and those who had died (p B 0.01). At 4 months, mean relative decline was 7.0% for HVLT-R Delayed Recall and 18.0% for ISLT Delayed Recall. OCLT showed an 8.0% increase. A reliable change index found no significant changes from baseline to 2 and 4 months for ISLT Delayed Recall (z =-0.40, p = 0.34; z =-0.68, p = 0.25) or OCLT (z = 0.15, p = 0.56; z = 0.41, p = 0.66). Study findings support the possibility that hippocampal avoidance may be associated with preservation of memory test performance, and that these computerized tests also may be useful and valid memory assessments in multi-institution adult brain tumor trials.

KW - HVLT-R

KW - ISLT

KW - Neurocognitive

KW - NRG Oncology RTOG 0933

KW - OCLT

UR - http://www.scopus.com/inward/record.url?scp=85007143602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007143602&partnerID=8YFLogxK

U2 - 10.1007/s11060-015-1971-2

DO - 10.1007/s11060-015-1971-2

M3 - Article

VL - 126

SP - 327

EP - 336

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

IS - 2

ER -