@article{4c61e9d5dc564bf8bb9228b6ddc3e05a,
title = "Cognitive functioning one month and one year following febrile status epilepticus",
abstract = "Objective The objective of this study was to determine early developmental and cognitive outcomes of children with febrile status epilepticus (FSE) one month and one year after FSE. Methods One hundred ninety four children with FSE were evaluated on measures of cognition, receptive language, and memory as part of the FEBSTAT study and compared with 100 controls with simple febrile seizures (FSs). Results Children with FSE did not differ dramatically on tasks compared with FS controls at one month after FSE but demonstrated slightly weaker motor development (p = 0.035) and receptive language (p = 0.034) at one year after FSE. Performances were generally within the low average to average range. Within the FSE cohort, non-White children performed weaker on many of the tasks compared with Caucasian children. At the one-year visit, acute hippocampal T2 findings on MRI were associated with weaker receptive language skills (p = 0.0009), and human herpes virus 6 or 7 (HHV6/7) viremia was associated with better memory performances (p = 0.047). Conclusion Febrile status epilepticus does not appear to be associated with significant cognitive impairment on early developmental measures, although there is a trend for possible receptive language and motor delay one year after FSE. Further follow-up, which is in progress, is necessary to track long-term cognitive functioning.",
keywords = "Children, Cognition, Febrile seizure, Febrile status epilepticus",
author = "Weiss, {Erica F.} and David Masur and Shlomo Shinnar and Hesdorffer, {Dale C.} and Hinton, {Veronica J.} and Melanie Bonner and Julie Rinaldi and {Van de Water}, Virginia and James Culbert and Shinnar, {Ruth C.} and Syndi Seinfeld and William Gallentine and Nordli, {Douglas R.} and Frank, {L. Mathew} and Leon Epstein and Mosh{\'e}, {Solomon L.} and Shumei Sun",
note = "Funding Information: Supported by NINDS grant 2R37 NS43209 (PI: S. Shinnar, MD, PhD), NICHD grant 36867 (PI: D.C. Hesdorffer PhD) and Center for Clinical and Translational Research grant UL1TR000058 . Funding Information: Dr. Shinnar is funded by NIH grants and serves on a DSMB for UCB Pharma. He has received personal compensation for serving on Scientific Advisory Boards for Accorda, AstraZenica, and Upsher Smith, for consulting for Accorda, AstraZenica, Neurelis, Upsher-Smith and Xeris. He has received royalties from Elsevier for coediting the book “Febrile Seizures”. He has also given expert testimony in medico-legal cases. Dr. Hesdorffer is funded by grants from NINDS, PCORI, CDC, PACE, Epilepsy Foundation, and The Epilepsy Study Consortium. She is a consultant to the Injury Prevention Center at Mount Sinai Medical Center and on the Advisory Boards for Acorda, UpsherSmith, and Cyberonics. She has had travel and hotel reimbursed by the International League Against Epilepsy meetings in 2014 and 2015. Dr. Mosh{\'e} is funded by grants from NIH, CURE, US Department of Defense, the Heffer Family and the Segal Family Foundations and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/Dan Levitz families. He is serving as Associate Editor of Neurobiology of Disease, and is on the editorial board of Epileptic Disorders, Brain and Development, Pediatric Neurology and Physiological Research. He receives from Elsevier an annual compensation for his work as Associate Editor in Neurobiology of Disease and royalties from 2 books he coedited. He received a consultant's fee from Eisai and UCB. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = nov,
day = "1",
doi = "10.1016/j.yebeh.2016.09.013",
language = "English (US)",
volume = "64",
pages = "283--288",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
}