Cognitive functioning one month and one year following febrile status epilepticus

Erica F. Weiss, David Masur, Shlomo Shinnar, Dale C. Hesdorffer, Veronica J. Hinton, Melanie Bonner, Julie Rinaldi, Virginia Van de Water, James Culbert, Ruth C. Shinnar, Syndi Seinfeld, William Gallentine, Douglas R. Nordli, L. Mathew Frank, Leon Epstein, Solomon L. Moshe, Shumei Sun

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective The objective of this study was to determine early developmental and cognitive outcomes of children with febrile status epilepticus (FSE) one month and one year after FSE. Methods One hundred ninety four children with FSE were evaluated on measures of cognition, receptive language, and memory as part of the FEBSTAT study and compared with 100 controls with simple febrile seizures (FSs). Results Children with FSE did not differ dramatically on tasks compared with FS controls at one month after FSE but demonstrated slightly weaker motor development (p = 0.035) and receptive language (p = 0.034) at one year after FSE. Performances were generally within the low average to average range. Within the FSE cohort, non-White children performed weaker on many of the tasks compared with Caucasian children. At the one-year visit, acute hippocampal T2 findings on MRI were associated with weaker receptive language skills (p = 0.0009), and human herpes virus 6 or 7 (HHV6/7) viremia was associated with better memory performances (p = 0.047). Conclusion Febrile status epilepticus does not appear to be associated with significant cognitive impairment on early developmental measures, although there is a trend for possible receptive language and motor delay one year after FSE. Further follow-up, which is in progress, is necessary to track long-term cognitive functioning.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalEpilepsy and Behavior
Volume64
DOIs
StatePublished - Nov 1 2016

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Status Epilepticus
Fever
Febrile Seizures
Language
Language Development Disorders
Viremia
Cognition
Viruses

Keywords

  • Children
  • Cognition
  • Febrile seizure
  • Febrile status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Cognitive functioning one month and one year following febrile status epilepticus. / Weiss, Erica F.; Masur, David; Shinnar, Shlomo; Hesdorffer, Dale C.; Hinton, Veronica J.; Bonner, Melanie; Rinaldi, Julie; Van de Water, Virginia; Culbert, James; Shinnar, Ruth C.; Seinfeld, Syndi; Gallentine, William; Nordli, Douglas R.; Frank, L. Mathew; Epstein, Leon; Moshe, Solomon L.; Sun, Shumei.

In: Epilepsy and Behavior, Vol. 64, 01.11.2016, p. 283-288.

Research output: Contribution to journalArticle

Weiss, EF, Masur, D, Shinnar, S, Hesdorffer, DC, Hinton, VJ, Bonner, M, Rinaldi, J, Van de Water, V, Culbert, J, Shinnar, RC, Seinfeld, S, Gallentine, W, Nordli, DR, Frank, LM, Epstein, L, Moshe, SL & Sun, S 2016, 'Cognitive functioning one month and one year following febrile status epilepticus', Epilepsy and Behavior, vol. 64, pp. 283-288. https://doi.org/10.1016/j.yebeh.2016.09.013
Weiss, Erica F. ; Masur, David ; Shinnar, Shlomo ; Hesdorffer, Dale C. ; Hinton, Veronica J. ; Bonner, Melanie ; Rinaldi, Julie ; Van de Water, Virginia ; Culbert, James ; Shinnar, Ruth C. ; Seinfeld, Syndi ; Gallentine, William ; Nordli, Douglas R. ; Frank, L. Mathew ; Epstein, Leon ; Moshe, Solomon L. ; Sun, Shumei. / Cognitive functioning one month and one year following febrile status epilepticus. In: Epilepsy and Behavior. 2016 ; Vol. 64. pp. 283-288.
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AU - Weiss, Erica F.

AU - Masur, David

AU - Shinnar, Shlomo

AU - Hesdorffer, Dale C.

AU - Hinton, Veronica J.

AU - Bonner, Melanie

AU - Rinaldi, Julie

AU - Van de Water, Virginia

AU - Culbert, James

AU - Shinnar, Ruth C.

AU - Seinfeld, Syndi

AU - Gallentine, William

AU - Nordli, Douglas R.

AU - Frank, L. Mathew

AU - Epstein, Leon

AU - Moshe, Solomon L.

AU - Sun, Shumei

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