Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA

Mahalia S. Desruisseaux, Maria Gulinello, David N. Smith, Sun Hee C. Lee, Moriya Tsuji, Louis M. Weiss, David C. Spray, Herbert B. Tanowitz

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Cerebral malaria complicated by cognitive sequelae is a major cause of morbidity in humans infected with Plasmodium falciparum. To model cognitive function after malaria, we created a rodent model of cerebral malaria by infecting C57BL/6 mice with Plasmodium berghei strainANKA.After 7 days, an object-recognition test of working memory revealed a significant impairment in the visual memory of infected mice. This impairment was observed in the absence of confounding effects of infection. The cognitive dysfunction correlated with hemorrhage and inflammation. Furthermore, microglial activity and morphological changes detected throughout the brains of infected mice were absent from the brains of control mice, and this correlated with the measured cognitive defects. Similar testing methods in human studies could help identify subjects at risk for an adverse cognitive outcome. This murine model should facilitate the study of adjunctive methods to ameliorate adverse neurological outcomes in cerebral malaria.

Original languageEnglish (US)
Pages (from-to)1621-1627
Number of pages7
JournalJournal of Infectious Diseases
Volume197
Issue number11
DOIs
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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