TY - JOUR
T1 - Cognitive dysfunction in autoimmune rheumatic diseases
AU - Oláh, Csaba
AU - Schwartz, Noa
AU - Denton, Christopher
AU - Kardos, Zsófia
AU - Putterman, Chaim
AU - Szekanecz, Zoltán
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/4/15
Y1 - 2020/4/15
N2 - For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.
AB - For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.
KW - Cognitive dysfunction
KW - Cognitive function
KW - Neuropsychiatric lupus
KW - Rheumatoid arthritis
KW - Systemic lupus erythematosus
KW - Systemic sclerosis
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U2 - 10.1186/s13075-020-02180-5
DO - 10.1186/s13075-020-02180-5
M3 - Review article
C2 - 32293528
AN - SCOPUS:85083376620
SN - 1478-6354
VL - 22
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
IS - 1
M1 - 78
ER -