Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause

Kelly N. Morgan; Carol A. Derby; Carey E. Gleason

doi:10.1016/j.ogc.2018.07.011

Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause

Kelly N. Morgan, Carol A. Derby, Carey E. Gleason

Neurology

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date, evidence for the “timing hypothesis,” and closes with recommendations for future research and for practicing clinicians.

Original language	English (US)
Pages (from-to)	751-763
Number of pages	13
Journal	Obstetrics and Gynecology Clinics of North America
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.ogc.2018.07.011
State	Published - Dec 2018

Keywords

Cognition
Early versus late intervention trial with estradiol
Estrogens
Hormone therapy
Kronos early estrogen prevention study
Menopause
Study of women across the nation
Women's Health Initiative

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ogc.2018.07.011

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title = "Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause",

abstract = "This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date, evidence for the “timing hypothesis,” and closes with recommendations for future research and for practicing clinicians.",

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year = "2018",

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AU - Derby, Carol A.

AU - Gleason, Carey E.

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AB - This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date, evidence for the “timing hypothesis,” and closes with recommendations for future research and for practicing clinicians.

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KW - Early versus late intervention trial with estradiol

KW - Estrogens

KW - Hormone therapy

KW - Kronos early estrogen prevention study

KW - Menopause

KW - Study of women across the nation

KW - Women's Health Initiative

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Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause

Abstract

Keywords

ASJC Scopus subject areas

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