Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude

A panel study

Xiaoming Chen, Qian Zhang, Jiye Wang, Jie Liu, Wenbin Zhang, Shun Qi, Hui Xu, Chen Li, Jinsong Zhang, Haitao Zhao, Shanshan Meng, Dan Li, Huanyu Lu, Michael Aschner, Bin Li, Hong Yin, Jingyuan Chen, Wenjing Luo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Cognitive and neuroimaging changes under chronic high-altitude exposure have never been followed up and dynamically assessed. Objectives: To investigate the cognitive and brain structural/functional alterations associated with chronic high-altitude exposure. Methods: Sixty-nine college freshmen that were immigrating to Tibet were enrolled and followed up for two years. Neuropsychological tests, including verbal/visual memory and simple/recognition reaction time, were utilized to determine whether the subjects' cognitive function had changed in response to chronic high-altitude exposure. Structural magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were used to quantify brain gray matter (GM) volumes, regional homogeneity (ReHo) and functional connectivity (FC) alterations before and after exposure. Areas with changes in both GM and ReHo were used as seeds in the inter-regional FC analysis. Results: The subjects showed significantly lower accuracy in memory tests and longer reaction times after exposure, and neuroimaging analysis showed markedly decreased GM volumes and ReHo in the left putamen. FC analysis seeding of the left putamen showed significantly weakened FC with the superior temporal gyrus, anterior/middle cingulate gyrus and other brain regions. In addition, decreased ReHo was found in the superior temporal gyrus, superior parietal lobule, anterior cingulate gyrus and medial frontal gyrus, while increased ReHo was found in the hippocampus. Differences in ReHo/FC before and after high-altitude exposure in multiple regions were significantly correlated with the cognitive changes. Conclusion: Cognitive functions such as working memory and psychomotor function are impaired during chronic high-altitude exposure. The putamen may play an important role in chronic hypoxia-induced cognitive impairment.

Original languageEnglish (US)
JournalHuman Brain Mapping
DOIs
StateAccepted/In press - 2017

Fingerprint

Neuroimaging
Putamen
Gyrus Cinguli
Temporal Lobe
Cognition
Reaction Time
Brain
Magnetic Resonance Imaging
Tibet
Parietal Lobe
Neuropsychological Tests
Prefrontal Cortex
Short-Term Memory
Hippocampus
Seeds
Gray Matter

Keywords

  • Cognition
  • High-altitude exposure
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude : A panel study. / Chen, Xiaoming; Zhang, Qian; Wang, Jiye; Liu, Jie; Zhang, Wenbin; Qi, Shun; Xu, Hui; Li, Chen; Zhang, Jinsong; Zhao, Haitao; Meng, Shanshan; Li, Dan; Lu, Huanyu; Aschner, Michael; Li, Bin; Yin, Hong; Chen, Jingyuan; Luo, Wenjing.

In: Human Brain Mapping, 2017.

Research output: Contribution to journalArticle

Chen, X, Zhang, Q, Wang, J, Liu, J, Zhang, W, Qi, S, Xu, H, Li, C, Zhang, J, Zhao, H, Meng, S, Li, D, Lu, H, Aschner, M, Li, B, Yin, H, Chen, J & Luo, W 2017, 'Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude: A panel study', Human Brain Mapping. https://doi.org/10.1002/hbm.23635
Chen, Xiaoming ; Zhang, Qian ; Wang, Jiye ; Liu, Jie ; Zhang, Wenbin ; Qi, Shun ; Xu, Hui ; Li, Chen ; Zhang, Jinsong ; Zhao, Haitao ; Meng, Shanshan ; Li, Dan ; Lu, Huanyu ; Aschner, Michael ; Li, Bin ; Yin, Hong ; Chen, Jingyuan ; Luo, Wenjing. / Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude : A panel study. In: Human Brain Mapping. 2017.
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abstract = "Background: Cognitive and neuroimaging changes under chronic high-altitude exposure have never been followed up and dynamically assessed. Objectives: To investigate the cognitive and brain structural/functional alterations associated with chronic high-altitude exposure. Methods: Sixty-nine college freshmen that were immigrating to Tibet were enrolled and followed up for two years. Neuropsychological tests, including verbal/visual memory and simple/recognition reaction time, were utilized to determine whether the subjects' cognitive function had changed in response to chronic high-altitude exposure. Structural magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were used to quantify brain gray matter (GM) volumes, regional homogeneity (ReHo) and functional connectivity (FC) alterations before and after exposure. Areas with changes in both GM and ReHo were used as seeds in the inter-regional FC analysis. Results: The subjects showed significantly lower accuracy in memory tests and longer reaction times after exposure, and neuroimaging analysis showed markedly decreased GM volumes and ReHo in the left putamen. FC analysis seeding of the left putamen showed significantly weakened FC with the superior temporal gyrus, anterior/middle cingulate gyrus and other brain regions. In addition, decreased ReHo was found in the superior temporal gyrus, superior parietal lobule, anterior cingulate gyrus and medial frontal gyrus, while increased ReHo was found in the hippocampus. Differences in ReHo/FC before and after high-altitude exposure in multiple regions were significantly correlated with the cognitive changes. Conclusion: Cognitive functions such as working memory and psychomotor function are impaired during chronic high-altitude exposure. The putamen may play an important role in chronic hypoxia-induced cognitive impairment.",
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T1 - Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude

T2 - A panel study

AU - Chen, Xiaoming

AU - Zhang, Qian

AU - Wang, Jiye

AU - Liu, Jie

AU - Zhang, Wenbin

AU - Qi, Shun

AU - Xu, Hui

AU - Li, Chen

AU - Zhang, Jinsong

AU - Zhao, Haitao

AU - Meng, Shanshan

AU - Li, Dan

AU - Lu, Huanyu

AU - Aschner, Michael

AU - Li, Bin

AU - Yin, Hong

AU - Chen, Jingyuan

AU - Luo, Wenjing

PY - 2017

Y1 - 2017

N2 - Background: Cognitive and neuroimaging changes under chronic high-altitude exposure have never been followed up and dynamically assessed. Objectives: To investigate the cognitive and brain structural/functional alterations associated with chronic high-altitude exposure. Methods: Sixty-nine college freshmen that were immigrating to Tibet were enrolled and followed up for two years. Neuropsychological tests, including verbal/visual memory and simple/recognition reaction time, were utilized to determine whether the subjects' cognitive function had changed in response to chronic high-altitude exposure. Structural magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were used to quantify brain gray matter (GM) volumes, regional homogeneity (ReHo) and functional connectivity (FC) alterations before and after exposure. Areas with changes in both GM and ReHo were used as seeds in the inter-regional FC analysis. Results: The subjects showed significantly lower accuracy in memory tests and longer reaction times after exposure, and neuroimaging analysis showed markedly decreased GM volumes and ReHo in the left putamen. FC analysis seeding of the left putamen showed significantly weakened FC with the superior temporal gyrus, anterior/middle cingulate gyrus and other brain regions. In addition, decreased ReHo was found in the superior temporal gyrus, superior parietal lobule, anterior cingulate gyrus and medial frontal gyrus, while increased ReHo was found in the hippocampus. Differences in ReHo/FC before and after high-altitude exposure in multiple regions were significantly correlated with the cognitive changes. Conclusion: Cognitive functions such as working memory and psychomotor function are impaired during chronic high-altitude exposure. The putamen may play an important role in chronic hypoxia-induced cognitive impairment.

AB - Background: Cognitive and neuroimaging changes under chronic high-altitude exposure have never been followed up and dynamically assessed. Objectives: To investigate the cognitive and brain structural/functional alterations associated with chronic high-altitude exposure. Methods: Sixty-nine college freshmen that were immigrating to Tibet were enrolled and followed up for two years. Neuropsychological tests, including verbal/visual memory and simple/recognition reaction time, were utilized to determine whether the subjects' cognitive function had changed in response to chronic high-altitude exposure. Structural magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were used to quantify brain gray matter (GM) volumes, regional homogeneity (ReHo) and functional connectivity (FC) alterations before and after exposure. Areas with changes in both GM and ReHo were used as seeds in the inter-regional FC analysis. Results: The subjects showed significantly lower accuracy in memory tests and longer reaction times after exposure, and neuroimaging analysis showed markedly decreased GM volumes and ReHo in the left putamen. FC analysis seeding of the left putamen showed significantly weakened FC with the superior temporal gyrus, anterior/middle cingulate gyrus and other brain regions. In addition, decreased ReHo was found in the superior temporal gyrus, superior parietal lobule, anterior cingulate gyrus and medial frontal gyrus, while increased ReHo was found in the hippocampus. Differences in ReHo/FC before and after high-altitude exposure in multiple regions were significantly correlated with the cognitive changes. Conclusion: Cognitive functions such as working memory and psychomotor function are impaired during chronic high-altitude exposure. The putamen may play an important role in chronic hypoxia-induced cognitive impairment.

KW - Cognition

KW - High-altitude exposure

KW - Magnetic resonance imaging

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DO - 10.1002/hbm.23635

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JO - Human Brain Mapping

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