Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

Mousumi Ghosh, Xiaoyan Song, Ghassan Mouneimne, Mazen Sidani, David S. Lawrence, John S. Condeelis

Research output: Contribution to journalArticle

500 Citations (Scopus)

Abstract

A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor.

Original languageEnglish (US)
Pages (from-to)743-746
Number of pages4
JournalScience
Volume304
Issue number5671
DOIs
StatePublished - Apr 30 2004

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Actin Depolymerizing Factors
Polymerization
Cell Movement
Actins
Destrin
Phosphorylation
Light
Direction compound
Proteins

ASJC Scopus subject areas

  • General

Cite this

Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility. / Ghosh, Mousumi; Song, Xiaoyan; Mouneimne, Ghassan; Sidani, Mazen; Lawrence, David S.; Condeelis, John S.

In: Science, Vol. 304, No. 5671, 30.04.2004, p. 743-746.

Research output: Contribution to journalArticle

Ghosh, M, Song, X, Mouneimne, G, Sidani, M, Lawrence, DS & Condeelis, JS 2004, 'Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility', Science, vol. 304, no. 5671, pp. 743-746. https://doi.org/10.1126/science.1094561
Ghosh, Mousumi ; Song, Xiaoyan ; Mouneimne, Ghassan ; Sidani, Mazen ; Lawrence, David S. ; Condeelis, John S. / Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility. In: Science. 2004 ; Vol. 304, No. 5671. pp. 743-746.
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