Coccidioides posadasii produces melanin in vitro and during infection

Joshua D. Nosanchuk; Jieh Juen Yu; Chiung Yu Hung; Arturo Casadevall; Garry T. Cole

doi:10.1016/j.fgb.2006.09.006

Coccidioides posadasii produces melanin in vitro and during infection

Joshua D. Nosanchuk, Jieh Juen Yu, Chiung Yu Hung, Arturo Casadevall, Garry T. Cole

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.

Original language	English (US)
Pages (from-to)	517-520
Number of pages	4
Journal	Fungal Genetics and Biology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/j.fgb.2006.09.006
State	Published - Jun 2007

Keywords

Coccidioides
Fungi
Melanin
Virulence factor

ASJC Scopus subject areas

Microbiology
Genetics

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10.1016/j.fgb.2006.09.006

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title = "Coccidioides posadasii produces melanin in vitro and during infection",

abstract = "Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.",

keywords = "Coccidioides, Fungi, Melanin, Virulence factor",

author = "Nosanchuk, {Joshua D.} and Yu, {Jieh Juen} and Hung, {Chiung Yu} and Arturo Casadevall and Cole, {Garry T.}",

note = "Funding Information: J.D.N. and A.C. were supported in part by a Public Health Service grant (AI52733) from the National Institutes of Health (NIH). Support for this study was also provided to G.T.C. by NIH Grants AI19149 and AI37232.",

year = "2007",

month = jun,

doi = "10.1016/j.fgb.2006.09.006",

language = "English (US)",

volume = "44",

pages = "517--520",

journal = "Fungal Genetics and Biology",

issn = "1087-1845",

publisher = "Academic Press Inc.",

number = "6",

}

TY - JOUR

T1 - Coccidioides posadasii produces melanin in vitro and during infection

AU - Nosanchuk, Joshua D.

AU - Yu, Jieh Juen

AU - Hung, Chiung Yu

AU - Casadevall, Arturo

AU - Cole, Garry T.

N1 - Funding Information: J.D.N. and A.C. were supported in part by a Public Health Service grant (AI52733) from the National Institutes of Health (NIH). Support for this study was also provided to G.T.C. by NIH Grants AI19149 and AI37232.

PY - 2007/6

Y1 - 2007/6

N2 - Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.

AB - Using techniques developed to study melanization in other fungi, we demonstrate that Coccidioides posadasii arthroconidia, spherules, and endospores produce melanin or melanin-like compounds in vitro and tissue forms synthesize pigment in vivo. Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis.

KW - Coccidioides

KW - Fungi

KW - Melanin

KW - Virulence factor

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DO - 10.1016/j.fgb.2006.09.006

M3 - Article

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AN - SCOPUS:34247640879

SN - 1087-1845

VL - 44

SP - 517

EP - 520

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

IS - 6

ER -

Coccidioides posadasii produces melanin in vitro and during infection

Abstract

Keywords

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