Co-morbidity, not age predicts adverse outcome in clostridium difficile colitis

Thiruvinvamalai S. Dharmarajan, M. Sipalay, R. Shyamsundar, E. P. Norkus, C. S. Pitchumoni

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Aim: To examine whether age alone or co-morbidity is a risk factor for death in older adults who developed Clostridium difficile (Cd) colitis during hospitalization. Methods: A retrospective, observational study design was performed in our Lady of Mercy Medical Center, a 650-bed, urban, community-based, university-affiliated teaching hospital. 121 patients with a positive diagnosis of Cd colitis (aged 23 - 97 years) were studied, and data pertinent to demographic variables, medical history, co-morbidity, physical examination, and laboratory results were collected. Age was examined as a continuous variable and stratified into Age1 (<80 vs 80+); Age2 (<60, 60 - 69, 70 - 79 and 80+); or Age3 (<60, 60 - 69, 70 - 79, 80 - 89, 90+). Results: Cd colitis occurs more frequently with advancing age (55% of cases >80 years). However, age, per se, had no effect on mortality. A history of cardiac disease (P = 0.036), recurrent or refractory infection >4 weeks (P = 0.007), low serum total protein (P = 0.034), low serum albumin (P = 0.001), antibiotic use >4 weeks (P < 0.010), use of over 4 antibiotics (P = 0.026), and use of certain classes of antibiotics (P = 0.035 - 0.004) were predictive of death. Death was strongly predicted by the use of penicillin-like antibiotics plus clindamycin, in the presence of hypoalbuminemia, refractory sepsis, and cardiac disease (P = 0.00005). Conclusion: Cd colitis is common in the very old. However, unlike co-morbidity, age alone does not affect the clinical outcome (survival vs death).

Original languageEnglish (US)
Pages (from-to)198-201
Number of pages4
JournalWorld Journal of Gastroenterology
Volume6
Issue number2
StatePublished - Apr 2000
Externally publishedYes

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Clostridium difficile
Colitis
Morbidity
Anti-Bacterial Agents
Heart Diseases
Hypoalbuminemia
Clindamycin
Serum Albumin
Teaching Hospitals
Penicillins
Physical Examination
Observational Studies
Blood Proteins
Sepsis
Hospitalization
Retrospective Studies
Demography
Survival
Mortality
Infection

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Dharmarajan, T. S., Sipalay, M., Shyamsundar, R., Norkus, E. P., & Pitchumoni, C. S. (2000). Co-morbidity, not age predicts adverse outcome in clostridium difficile colitis. World Journal of Gastroenterology, 6(2), 198-201.

Co-morbidity, not age predicts adverse outcome in clostridium difficile colitis. / Dharmarajan, Thiruvinvamalai S.; Sipalay, M.; Shyamsundar, R.; Norkus, E. P.; Pitchumoni, C. S.

In: World Journal of Gastroenterology, Vol. 6, No. 2, 04.2000, p. 198-201.

Research output: Contribution to journalArticle

Dharmarajan, TS, Sipalay, M, Shyamsundar, R, Norkus, EP & Pitchumoni, CS 2000, 'Co-morbidity, not age predicts adverse outcome in clostridium difficile colitis', World Journal of Gastroenterology, vol. 6, no. 2, pp. 198-201.
Dharmarajan, Thiruvinvamalai S. ; Sipalay, M. ; Shyamsundar, R. ; Norkus, E. P. ; Pitchumoni, C. S. / Co-morbidity, not age predicts adverse outcome in clostridium difficile colitis. In: World Journal of Gastroenterology. 2000 ; Vol. 6, No. 2. pp. 198-201.
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AU - Norkus, E. P.

AU - Pitchumoni, C. S.

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