Clostridium difficile‐Associated Diarrhea in Patients with HIV Positivity and AIDS: A Prospective Controlled Study

Sain Sain Lu, Jonathan M. Schwartz, Douglas M. Simon, Lawrence J. Brandt

Research output: Contribution to journalArticle

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Objective: To compare the clinical manifestations and therapeutic responses of Clostridium difficile infection in HIV‐infected and noninfected individuals. Methods: Patients were identified for this study if they had C. difficile toxin in the stool. The patients were then followed prospectively by the investigators. All patients were treated with a standard regimen, and clinical and laboratory findings were recorded. Persistence and resolution or recurrence of symptoms and complications were recorded. Results: A total of 87 patients were studied, of which 12 were HIV positive, 20 had AIDS, and 55 had no known HIV infection. The AIDS group was younger and had a lower total leukocyte count than the controls. There were no statistically significant differences in temperature, leukocytosis, clinical symptoms, therapeutic response, or recurrence or persistent of symptoms. Conclusions: Despite the immuno‐suppression of HIV infection, C. difficile infection behaves no differently in HIV/AIDS patients than it does in controls.

Original languageEnglish (US)
Pages (from-to)1226-1229
Number of pages4
JournalThe American Journal of Gastroenterology
Issue number8
StatePublished - Aug 1994


ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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