Clostridium difficile-associated diarrhea in patients with HIV positivity and AIDS

A prospective controlled study

Sain Lu Sain Sain Lu, Jonathan M. Schwartz, D. M. Simon, Lawrence J. Brandt

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: To compare the clinical manifestations and therapeutic responses of Clostridium difficile infection in HIV-infected and noninfected individuals. Methods: Patients were identified for this study if they had C. difficile toxin in the stool. The patients were then followed prospectively by the investigators. All patients were treated with a standard regimen, and clinical and laboratory findings were recorded. Persistence and resolution or recurrence of symptoms and complications were recorded. Results: A total of 87 patients were studied, of which 12 were HIV positive, 20 had AIDS, and 55 had no known HIV infection. The AIDS group was younger and had a lower total leukocyte count than the controls. There were no statistically significant differences in temperature, leukocytosis, clinical symptoms, therapeutic response, or recurrence or persistent of symptoms. Conclusions: Despite the immunosuppression of HIV infection, C. difficile infection behaves no differently in HIV/AIDS patients than it does in controls.

Original languageEnglish (US)
Pages (from-to)1226-1229
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume89
Issue number8
StatePublished - 1994

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Clostridium difficile
Diarrhea
Acquired Immunodeficiency Syndrome
HIV
Prospective Studies
Clostridium Infections
HIV Infections
Recurrence
Leukocytosis
Leukocyte Count
Immunosuppression
Research Personnel
Temperature
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clostridium difficile-associated diarrhea in patients with HIV positivity and AIDS : A prospective controlled study. / Sain Sain Lu, Sain Lu; Schwartz, Jonathan M.; Simon, D. M.; Brandt, Lawrence J.

In: American Journal of Gastroenterology, Vol. 89, No. 8, 1994, p. 1226-1229.

Research output: Contribution to journalArticle

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