Closing the loop: Practical and theoretical

C. M. Peterson, L. B. Jovanovic, M. Brownlee, R. L. Jones, A. Cerami

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Using presently available technologies, a closed-loop system can be devised that employs patient-monitored glucose determinations and self-adjusted insulin administration. Improved glucose control has been documented in type I diabetes and in pregnant women with insulin-dependent diabetes mellitus. In pregnancy, self-administered insulin may achieve levels of carbohydrate control that are superior to those achieved using a self-contained glucose-controlled insulin infusion system, programmed by existing algorithms. Improved closed-loop systems are necessary in order to achieve carbohydrate 'control' that will surpass that which can be attained using presently available means. A potential approach might employ a lectin glucose-controlled insulin delivery system.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalDiabetes care
Issue number2
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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