TY - JOUR
T1 - Closing the gap
T2 - long-term presynaptic plasticity in brain function and disease
AU - Monday, Hannah R.
AU - Castillo, Pablo E.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/8
Y1 - 2017/8
N2 - Synaptic plasticity is critical for experience-dependent adjustments of brain function. While most research has focused on the mechanisms that underlie postsynaptic forms of plasticity, comparatively little is known about how neurotransmitter release is altered in a long-term manner. Emerging research suggests that many of the features of canonical ‘postsynaptic’ plasticity, such as associativity, structural changes and bidirectionality, also characterize long-term presynaptic plasticity. Recent studies demonstrate that presynaptic plasticity is a potent regulator of circuit output and function. Moreover, aberrant presynaptic plasticity is a convergent factor of synaptopathies like schizophrenia, addiction, and Autism Spectrum Disorders, and may be a potential target for treatment.
AB - Synaptic plasticity is critical for experience-dependent adjustments of brain function. While most research has focused on the mechanisms that underlie postsynaptic forms of plasticity, comparatively little is known about how neurotransmitter release is altered in a long-term manner. Emerging research suggests that many of the features of canonical ‘postsynaptic’ plasticity, such as associativity, structural changes and bidirectionality, also characterize long-term presynaptic plasticity. Recent studies demonstrate that presynaptic plasticity is a potent regulator of circuit output and function. Moreover, aberrant presynaptic plasticity is a convergent factor of synaptopathies like schizophrenia, addiction, and Autism Spectrum Disorders, and may be a potential target for treatment.
UR - http://www.scopus.com/inward/record.url?scp=85019748888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019748888&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2017.05.011
DO - 10.1016/j.conb.2017.05.011
M3 - Review article
C2 - 28570863
AN - SCOPUS:85019748888
SN - 0959-4388
VL - 45
SP - 106
EP - 112
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -