Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.
|Original language||English (US)|
|Number of pages||3|
|Publication status||Published - Dec 1991|
ASJC Scopus subject areas
- Cancer Research