Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations

G. Cimino, D. T. Moir, O. Canaani, K. Williams, W. M. Crist, S. Katzav, L. Cannizzaro, B. Lange, P. C. Nowell, C. M. Croce, E. Canaani

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183 Scopus citations

Abstract

Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.

Original languageEnglish (US)
Pages (from-to)6712-6714
Number of pages3
JournalCancer Research
Volume51
Issue number24
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Cimino, G., Moir, D. T., Canaani, O., Williams, K., Crist, W. M., Katzav, S., Cannizzaro, L., Lange, B., Nowell, P. C., Croce, C. M., & Canaani, E. (1991). Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations. Cancer Research, 51(24), 6712-6714.