Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations

G. Cimino, D. T. Moir, O. Canaani, K. Williams, W. M. Crist, S. Katzav, L. Cannizzaro, B. Lange, P. C. Nowell, C. M. Croce, E. Canaani

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.

Original languageEnglish (US)
Pages (from-to)6712-6714
Number of pages3
JournalCancer research
Volume51
Issue number24
StatePublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations'. Together they form a unique fingerprint.

Cite this