Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis

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Abstract

Diaminopimelate (DAP) is used by bacteria for the synthesis of lysine. In many species of bacteria, including mycobacteria, DAP is also used for peptidoglycan biosynthesis. In this report we describe the cloning of the dapB gene encoding dihydrodipicolinate reductase (DHPR), which catalyzes a key branch point reaction in the bacterial DAP biosynthetic pathway, from Mycobacterium tuberculosis. Analyses of the DapB proteins from different bacterial species suggest that two different classes of DHPR enzymes may exist in bacteria.

Original languageEnglish (US)
Pages (from-to)2777-2782
Number of pages6
JournalJournal of Bacteriology
Volume179
Issue number8
DOIs
Publication statusPublished - Jan 1 1997

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ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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