Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis

Research output: Contribution to journalArticle

16 Scopus citations


Diaminopimelate (DAP) is used by bacteria for the synthesis of lysine. In many species of bacteria, including mycobacteria, DAP is also used for peptidoglycan biosynthesis. In this report we describe the cloning of the dapB gene encoding dihydrodipicolinate reductase (DHPR), which catalyzes a key branch point reaction in the bacterial DAP biosynthetic pathway, from Mycobacterium tuberculosis. Analyses of the DapB proteins from different bacterial species suggest that two different classes of DHPR enzymes may exist in bacteria.

Original languageEnglish (US)
Pages (from-to)2777-2782
Number of pages6
JournalJournal of Bacteriology
Issue number8
Publication statusPublished - Jan 1 1997


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this