Cloning and expression of human GTDC1 gene (glycosyltransferase-like domain containing 1) from human fetal library

Enpeng Zhao, Yao Li, Xuping Fu, Jia Yi Zhang, Huawu Zeng, Li Zeng, Yun Lin, Jinzhong Chen, Gang Yin, Ji Qian, Kang Ying, Yi Xie, Robert Chunhua Zhao, Yu Min Mao

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The glycosyltransferases (GTs) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Here we report the cloning and characterization of a novel human GTDC1 (glycosyltransferase-like domain containing 1) gene, which locates on human chromosome 2q22. The GTDC1 cDNA is 2954 bp in length, encoding a putative protein of 458 amino acids. At protein level human GTDC1 has 75 and 37% identity with its homologous counterparts in the mouse and fruitfly, respectively. RT-PCR analysis revealed its relatively high expression level in the adult lung, spleen, testis, and peripheral blood leukocyte.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalDNA and Cell Biology
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 1 2004

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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