Clonal Rearrangement of Chromosome Band 6p21 in the Mesenchymal Component of Pulmonary Chondroid Hamartoma

Jonathan A. Fletcher, Geraldine S. Pinkus, Kevin Donovan, Rizwan Naeem, Jack L. Pinkus, Janina Longtine

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Abstract

Pulmonary chondroid hamartomas (PCH) are biphasic benign tumors that contain both mesenchymal and epithelial populations. In this report we describe two PCH in which clonal translocations at chromosome band 6p21 were demonstrated in mesenchymal cells. One of these had a unique translocation, t(6;14Xp21;q24), that was also found in one of two PCH karyotyped previously. The t(6;14) has not been described in other varieties of benign or malignant neoplasia. The 6p21 aberrations are of particular interest because break points in this chromosomal region appear to be characteristic of endometrial polyps. Endometrial polyps, like PCH, are biphasic benign tumors in which mesenchymal clonalSty has been demonstrated.

Original languageEnglish (US)
Pages (from-to)6224-6228
Number of pages5
JournalCancer Research
Volume52
Issue number22
Publication statusPublished - Nov 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Fletcher, J. A., Pinkus, G. S., Donovan, K., Naeem, R., Pinkus, J. L., & Longtine, J. (1992). Clonal Rearrangement of Chromosome Band 6p21 in the Mesenchymal Component of Pulmonary Chondroid Hamartoma. Cancer Research, 52(22), 6224-6228.