Clonal growth in vitro by mouse Kupffer cells

Dien Ming Chen, Hsiu San Lin, Philip Stahl, E. Richard Stanley

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Abstract

Mouse liver Kupffer cells were induced to proliferate and form discrete colonies of mononuclear phagocytes in vitro. These colony-forming cells from the liver are similar to other mononuclear phagocyte colony-forming cells in that they require a colony-stimulating factor present in medium conditioned by L cells for proliferation in vitro. Cells in the colonies were phagocytic and had IgG receptors on the membrane. For this class of colony-forming cells, the D0 value to gamma irradiation in vitro was 108 rads.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalExperimental Cell Research
Volume121
Issue number1
DOIs
Publication statusPublished - Jun 1979

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ASJC Scopus subject areas

  • Cell Biology

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Chen, D. M., Lin, H. S., Stahl, P., & Stanley, E. R. (1979). Clonal growth in vitro by mouse Kupffer cells. Experimental Cell Research, 121(1), 103-109. https://doi.org/10.1016/0014-4827(79)90449-X