Clonal chromosome aberrations with monosomy of chromosome 8 in a case of grade III chondrosarcoma

Konrad Ptaszynski, K. H. Ramesh, Linda A. Cannizzaro

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Abstract

We report cytogenetic findings in a case of grade III chondrosarcoma. Complex clonal chromosome aberrations including monosomy of chromosomes 4, 8, 13, and a consistent t(5;14)(q23;p12) were observed in all cells. There were no structural or numerical anomalies involving chromosome 12. The complexity of the chromosome aberrations reflect the advanced stage of this chondrosarcoma; we suggest a possible involvement of the EXT1 gene located on chromosome 8.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume97
Issue number1
DOIs
Publication statusPublished - Aug 1 1997

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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