Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog

G. Krinke, H. H. Schaumburg, P. S. Spencer, P. Thomann, R. Hess

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The central distal axonopathy induced in dogs by the administration of high doses of clioquinol is contrasted with the central-peripheral distal axonopathy precipitated by intoxication with 2,5-hexanedione. Mature, pure-bred Beagle dogs received a daily oral dose of 400 mg/kg of clioquinol for up to 7 months, or 1 ml per animal (approximately corresponding to 110 mg/kg) of 2,5-hexanedione for up to 5 months. Intoxicated and control animals were killed and perfused at monthly intervals, so that the spatial-temporal development of the lesion could be followed and correlated with clinical symptoms. During the treatment, dogs intoxicated with 2,5-hexanedione developed symptoms of peripheral neuropathy consisting of flaccid weakness, muscle atrophy, hind-limb foot-drop and areflexia. By contrast, the dogs surviving clioquinol intoxication exhibited a stiff-legged gait, hyperreflexia but no muscle atrophy. Light and electron microscope examination of central and peripheral nervous tissue from dogs intoxicated with 2,5-hexanedione revealed giant axonal swelling and distal axonal degeneration. By contrast, dogs receiving clioquinol showed a distal axonal degeneration confined to the optic tract and the long spinal cord tracts, without any visible involvement of peripheral nerves.

Original languageEnglish (US)
Pages (from-to)213-221
Number of pages9
JournalActa Neuropathologica
Volume47
Issue number3
DOIs
StatePublished - Jan 1979

Fingerprint

Clioquinol
Dogs
Muscular Atrophy
Nerve Tissue
Abnormal Reflexes
Peripheral Nervous System Diseases
Gait
Peripheral Nerves
2,5-hexanedione
Foot
Spinal Cord
Extremities
Electrons
Light

Keywords

  • 2,5-hexanedione
  • Clioquinol
  • Distal axonopathy
  • Dog
  • Intoxication

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Krinke, G., Schaumburg, H. H., Spencer, P. S., Thomann, P., & Hess, R. (1979). Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog. Acta Neuropathologica, 47(3), 213-221. https://doi.org/10.1007/BF00690549

Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog. / Krinke, G.; Schaumburg, H. H.; Spencer, P. S.; Thomann, P.; Hess, R.

In: Acta Neuropathologica, Vol. 47, No. 3, 01.1979, p. 213-221.

Research output: Contribution to journalArticle

Krinke, G, Schaumburg, HH, Spencer, PS, Thomann, P & Hess, R 1979, 'Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog', Acta Neuropathologica, vol. 47, no. 3, pp. 213-221. https://doi.org/10.1007/BF00690549
Krinke, G. ; Schaumburg, H. H. ; Spencer, P. S. ; Thomann, P. ; Hess, R. / Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog. In: Acta Neuropathologica. 1979 ; Vol. 47, No. 3. pp. 213-221.
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