Clinical validation and applications for CT-based atlas for contouring the lower cranial nerves for head and neck cancer radiation therapy

Waleed F. Mourad, Brett M. Young, Rebekah Young, Dukagjin M. Blakaj, Nitin Orhi, Rania A. Shourbaji, Spiros Manolidis, Mauricio Gámez, Mahesh Kumar, Azita Khorsandi, Majid A. Khan, Daniel Shasha, Adriana Blakaj, Jonathan Glanzman, Madhur K. Garg, Kenneth S. Hu, Shalom Kalnicki, Louis B. Harrison

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives Radiation induced cranial nerve palsy (RICNP) involving the lower cranial nerves (CNs) is a serious complication of head and neck radiotherapy (RT). Recommendations for delineating the lower CNs on RT planning studies do not exist. The aim of the current study is to develop a standardized methodology for contouring CNs IX-XII, which would help in establishing RT limiting doses for organs at risk (OAR). Methods Using anatomic texts, radiologic data, and guidance from experts in head and neck anatomy, we developed step-by-step instructions for delineating CNs IX-XII on computed tomography (CT) imaging. These structures were then contoured on five consecutive patients who underwent definitive RT for locally-advanced head and neck cancer (LAHNC). RT doses delivered to the lower CNs were calculated. Results We successfully developed a contouring atlas for CNs IX-XII. The median total dose to the planning target volume (PTV) was 70 Gy (range: 66-70 Gy). The median CN (IX-XI) and (XII) volumes were 10 c.c (range: 8-12 c.c) and 8 c.c (range: 7-10 c.c), respectively. The median V50, V60, V66, and V70 of the CN (IX-XI) and (XII) volumes were (85, 77, 71, 65) and (88, 80, 74, 64) respectively. The median maximal dose to the CN (IX-XI) and (XII) were 72 Gy (range: 66-77) and 71 Gy (range: 64-78), respectively. Conclusions We have generated simple instructions for delineating the lower CNs on RT planning imaging. Further analyses to explore the relationship between lower CN dosing and the risk of RICNP are recommended in order to establish limiting doses for these OARs.

Original languageEnglish (US)
Pages (from-to)956-963
Number of pages8
JournalOral Oncology
Volume49
Issue number9
DOIs
StatePublished - Sep 2013

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Glossopharyngeal Nerve
Cranial Nerves
Atlases
Head and Neck Neoplasms
Radiotherapy
Tomography
Accessory Nerve
Hypoglossal Nerve
Cranial Nerve Diseases
Neck
Head
Radiation
Organs at Risk
Median Nerve
Anatomy

Keywords

  • Base of skull, nasopharyngeal and Paranasalsinus cancer
  • Contouring atlas
  • Intensity-modulated radiotherapy (IMRT)
  • Locally Advanced Head-and-neck cancer (LAHNC)
  • Lower cranial nerves IX-XII palsy
  • Radiotherapy (RT)

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Clinical validation and applications for CT-based atlas for contouring the lower cranial nerves for head and neck cancer radiation therapy. / Mourad, Waleed F.; Young, Brett M.; Young, Rebekah; Blakaj, Dukagjin M.; Orhi, Nitin; Shourbaji, Rania A.; Manolidis, Spiros; Gámez, Mauricio; Kumar, Mahesh; Khorsandi, Azita; Khan, Majid A.; Shasha, Daniel; Blakaj, Adriana; Glanzman, Jonathan; Garg, Madhur K.; Hu, Kenneth S.; Kalnicki, Shalom; Harrison, Louis B.

In: Oral Oncology, Vol. 49, No. 9, 09.2013, p. 956-963.

Research output: Contribution to journalArticle

Mourad, WF, Young, BM, Young, R, Blakaj, DM, Orhi, N, Shourbaji, RA, Manolidis, S, Gámez, M, Kumar, M, Khorsandi, A, Khan, MA, Shasha, D, Blakaj, A, Glanzman, J, Garg, MK, Hu, KS, Kalnicki, S & Harrison, LB 2013, 'Clinical validation and applications for CT-based atlas for contouring the lower cranial nerves for head and neck cancer radiation therapy', Oral Oncology, vol. 49, no. 9, pp. 956-963. https://doi.org/10.1016/j.oraloncology.2013.03.449
Mourad, Waleed F. ; Young, Brett M. ; Young, Rebekah ; Blakaj, Dukagjin M. ; Orhi, Nitin ; Shourbaji, Rania A. ; Manolidis, Spiros ; Gámez, Mauricio ; Kumar, Mahesh ; Khorsandi, Azita ; Khan, Majid A. ; Shasha, Daniel ; Blakaj, Adriana ; Glanzman, Jonathan ; Garg, Madhur K. ; Hu, Kenneth S. ; Kalnicki, Shalom ; Harrison, Louis B. / Clinical validation and applications for CT-based atlas for contouring the lower cranial nerves for head and neck cancer radiation therapy. In: Oral Oncology. 2013 ; Vol. 49, No. 9. pp. 956-963.
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abstract = "Objectives Radiation induced cranial nerve palsy (RICNP) involving the lower cranial nerves (CNs) is a serious complication of head and neck radiotherapy (RT). Recommendations for delineating the lower CNs on RT planning studies do not exist. The aim of the current study is to develop a standardized methodology for contouring CNs IX-XII, which would help in establishing RT limiting doses for organs at risk (OAR). Methods Using anatomic texts, radiologic data, and guidance from experts in head and neck anatomy, we developed step-by-step instructions for delineating CNs IX-XII on computed tomography (CT) imaging. These structures were then contoured on five consecutive patients who underwent definitive RT for locally-advanced head and neck cancer (LAHNC). RT doses delivered to the lower CNs were calculated. Results We successfully developed a contouring atlas for CNs IX-XII. The median total dose to the planning target volume (PTV) was 70 Gy (range: 66-70 Gy). The median CN (IX-XI) and (XII) volumes were 10 c.c (range: 8-12 c.c) and 8 c.c (range: 7-10 c.c), respectively. The median V50, V60, V66, and V70 of the CN (IX-XI) and (XII) volumes were (85, 77, 71, 65) and (88, 80, 74, 64) respectively. The median maximal dose to the CN (IX-XI) and (XII) were 72 Gy (range: 66-77) and 71 Gy (range: 64-78), respectively. Conclusions We have generated simple instructions for delineating the lower CNs on RT planning imaging. Further analyses to explore the relationship between lower CN dosing and the risk of RICNP are recommended in order to establish limiting doses for these OARs.",
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T1 - Clinical validation and applications for CT-based atlas for contouring the lower cranial nerves for head and neck cancer radiation therapy

AU - Mourad, Waleed F.

AU - Young, Brett M.

AU - Young, Rebekah

AU - Blakaj, Dukagjin M.

AU - Orhi, Nitin

AU - Shourbaji, Rania A.

AU - Manolidis, Spiros

AU - Gámez, Mauricio

AU - Kumar, Mahesh

AU - Khorsandi, Azita

AU - Khan, Majid A.

AU - Shasha, Daniel

AU - Blakaj, Adriana

AU - Glanzman, Jonathan

AU - Garg, Madhur K.

AU - Hu, Kenneth S.

AU - Kalnicki, Shalom

AU - Harrison, Louis B.

PY - 2013/9

Y1 - 2013/9

N2 - Objectives Radiation induced cranial nerve palsy (RICNP) involving the lower cranial nerves (CNs) is a serious complication of head and neck radiotherapy (RT). Recommendations for delineating the lower CNs on RT planning studies do not exist. The aim of the current study is to develop a standardized methodology for contouring CNs IX-XII, which would help in establishing RT limiting doses for organs at risk (OAR). Methods Using anatomic texts, radiologic data, and guidance from experts in head and neck anatomy, we developed step-by-step instructions for delineating CNs IX-XII on computed tomography (CT) imaging. These structures were then contoured on five consecutive patients who underwent definitive RT for locally-advanced head and neck cancer (LAHNC). RT doses delivered to the lower CNs were calculated. Results We successfully developed a contouring atlas for CNs IX-XII. The median total dose to the planning target volume (PTV) was 70 Gy (range: 66-70 Gy). The median CN (IX-XI) and (XII) volumes were 10 c.c (range: 8-12 c.c) and 8 c.c (range: 7-10 c.c), respectively. The median V50, V60, V66, and V70 of the CN (IX-XI) and (XII) volumes were (85, 77, 71, 65) and (88, 80, 74, 64) respectively. The median maximal dose to the CN (IX-XI) and (XII) were 72 Gy (range: 66-77) and 71 Gy (range: 64-78), respectively. Conclusions We have generated simple instructions for delineating the lower CNs on RT planning imaging. Further analyses to explore the relationship between lower CN dosing and the risk of RICNP are recommended in order to establish limiting doses for these OARs.

AB - Objectives Radiation induced cranial nerve palsy (RICNP) involving the lower cranial nerves (CNs) is a serious complication of head and neck radiotherapy (RT). Recommendations for delineating the lower CNs on RT planning studies do not exist. The aim of the current study is to develop a standardized methodology for contouring CNs IX-XII, which would help in establishing RT limiting doses for organs at risk (OAR). Methods Using anatomic texts, radiologic data, and guidance from experts in head and neck anatomy, we developed step-by-step instructions for delineating CNs IX-XII on computed tomography (CT) imaging. These structures were then contoured on five consecutive patients who underwent definitive RT for locally-advanced head and neck cancer (LAHNC). RT doses delivered to the lower CNs were calculated. Results We successfully developed a contouring atlas for CNs IX-XII. The median total dose to the planning target volume (PTV) was 70 Gy (range: 66-70 Gy). The median CN (IX-XI) and (XII) volumes were 10 c.c (range: 8-12 c.c) and 8 c.c (range: 7-10 c.c), respectively. The median V50, V60, V66, and V70 of the CN (IX-XI) and (XII) volumes were (85, 77, 71, 65) and (88, 80, 74, 64) respectively. The median maximal dose to the CN (IX-XI) and (XII) were 72 Gy (range: 66-77) and 71 Gy (range: 64-78), respectively. Conclusions We have generated simple instructions for delineating the lower CNs on RT planning imaging. Further analyses to explore the relationship between lower CN dosing and the risk of RICNP are recommended in order to establish limiting doses for these OARs.

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KW - Intensity-modulated radiotherapy (IMRT)

KW - Locally Advanced Head-and-neck cancer (LAHNC)

KW - Lower cranial nerves IX-XII palsy

KW - Radiotherapy (RT)

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