TY - JOUR
T1 - Clinical utility of chromogranin A and octreotide in large cell neuro endocrine carcinoma of the uterine corpus
AU - Shahabi, Shohreh
AU - Pellicciotta, Ilenia
AU - Hou, June
AU - Graceffa, Sarah
AU - Huang, Gloria S.
AU - Samuelson, Robert N.
AU - Goldberg, Gary L.
PY - 2011
Y1 - 2011
N2 - Primary neuroendocrine tumors of the female genital tract have been described in the cervix, ovaries and uterus. Large cell neuroendocrine carcinoma (LCNC) of the uterine corpus is the least common and appears to behave the most aggressively. We report a rare case of a large cell neuroendocrine tumor of the endometrium. These tumors are not well characterized, unlike neuroendocrine tumors of the uterine cervix. Consequently, the optimal management remains still unclear. The treatment of our case consisted of surgery, radiotherapy, chemotherapy, and octreotide. Despite the aggressive treatment, the patient died of disease progression 12 months after the initial diagnosis. We discuss the diagnosis, prognosis, and treatment options for LCNC of the genital tract, and potential future therapeutics.
AB - Primary neuroendocrine tumors of the female genital tract have been described in the cervix, ovaries and uterus. Large cell neuroendocrine carcinoma (LCNC) of the uterine corpus is the least common and appears to behave the most aggressively. We report a rare case of a large cell neuroendocrine tumor of the endometrium. These tumors are not well characterized, unlike neuroendocrine tumors of the uterine cervix. Consequently, the optimal management remains still unclear. The treatment of our case consisted of surgery, radiotherapy, chemotherapy, and octreotide. Despite the aggressive treatment, the patient died of disease progression 12 months after the initial diagnosis. We discuss the diagnosis, prognosis, and treatment options for LCNC of the genital tract, and potential future therapeutics.
KW - Chromogranin A
KW - Large cell neuroendocrine carcinoma
KW - Octerotide
KW - Uterine corpus
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U2 - 10.4081/rt.2011.e41
DO - 10.4081/rt.2011.e41
M3 - Article
C2 - 22355496
AN - SCOPUS:80355144827
SN - 2036-3605
VL - 3
SP - 129
EP - 131
JO - Rare Tumors
JF - Rare Tumors
IS - 4
ER -