TY - JOUR
T1 - Clinical Strategies to Prevent Acute Respiratory Distress Syndrome
AU - Odeyemi, Yewande E.
AU - Herasevich, Svetlana
AU - Gong, Michelle N.
AU - Gajic, Ognjen O.
N1 - Publisher Copyright:
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York.
PY - 2019
Y1 - 2019
N2 - Acute respiratory distress syndrome (ARDS) remains an important clinical entity in the intensive care unit with a significant impact on morbidity and mortality. Effective therapeutic interventions are limited; thus current research focus has shifted from treatment to the prevention of this pulmonary syndrome. In recent decades, a decrease in the incidence of ARDS has been observed and this reduction is largely due to preventive strategies including safe lung ventilation practices, avoidance of iatrogenic exposures, and improvement in care of predisposing conditions such as sepsis and pneumonia. Early identification of at-risk patients, prompt treatment of predisposing conditions, and adoption of evidence-based best practice including restrictive transfusion strategies, conservative fluid management, avoidance of large tidal volume ventilation, and aspiration precaution practices are key preventive strategies with demonstrated benefits. There are currently no effective pharmacological preventive strategies for ARDS.
AB - Acute respiratory distress syndrome (ARDS) remains an important clinical entity in the intensive care unit with a significant impact on morbidity and mortality. Effective therapeutic interventions are limited; thus current research focus has shifted from treatment to the prevention of this pulmonary syndrome. In recent decades, a decrease in the incidence of ARDS has been observed and this reduction is largely due to preventive strategies including safe lung ventilation practices, avoidance of iatrogenic exposures, and improvement in care of predisposing conditions such as sepsis and pneumonia. Early identification of at-risk patients, prompt treatment of predisposing conditions, and adoption of evidence-based best practice including restrictive transfusion strategies, conservative fluid management, avoidance of large tidal volume ventilation, and aspiration precaution practices are key preventive strategies with demonstrated benefits. There are currently no effective pharmacological preventive strategies for ARDS.
KW - acute lung injury
KW - acute respiratory distress syndrome
KW - prevention
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U2 - 10.1055/s-0039-1683997
DO - 10.1055/s-0039-1683997
M3 - Article
C2 - 31060094
AN - SCOPUS:85065614886
SN - 1069-3424
VL - 40
SP - 129
EP - 136
JO - Seminars in Respiratory and Critical Care Medicine
JF - Seminars in Respiratory and Critical Care Medicine
IS - 1
ER -