Clinical relevance of chromosome abnormalities in non-small cell lung cancer

Madelyn Feder, Jill M. Siegfried, Andrew Balshem, Samuel Litwin, Steven M. Keller, Zemin Liu, Joseph R. Testa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The relationship between clonal chromosome alterations and various clinical parameters was evaluated in 70 patients with non-small cell lung cancer (NSCLC) for whom detailed karyotypic assessment was possible. Included in the analysis are karyotypes of 63 previously published cases and seven new NSCLCs. Clinical features investigated were diagnosis, tumor stage and grade, gender, smoking history measured in pack years, and survival. Certain chromosome abnormalities were significantly associated with histologic subtype, tumor grade, stage, and prognosis. Rearrangements involving chromosome arms 2p and 3q were more common in squamous cell carcinoma (SCC) than in adenocarcinoma (ADC). Loss of 3p was observed more often in SCC. Gain of 7p was more frequent in ADC. Rearrangement of 17p was associated with a lower tumor grade. Rearrangement of Xp and loss of chromosome 12 or 22 were each associated with higher tumor stage. Rearrangement of 3p or 6q was correlated with a better survival outlook. In contrast, loss of chromosomes 4 or 22 portended a poor prognosis. Finally, an increased number of marker chromosomes was observed in patients having a higher number of pack years. These data indicate that chromosome abnormalities can have clinical and pathologic significance in NSCLC.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume102
Issue number1
DOIs
StatePublished - Apr 1998
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Chromosome Aberrations
Chromosomes, Human, Pair 22
Squamous Cell Carcinoma
Neoplasms
Adenocarcinoma
Chromosomes
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 4
Survival
Karyotype
Genetic Markers
Smoking
History

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Feder, M., Siegfried, J. M., Balshem, A., Litwin, S., Keller, S. M., Liu, Z., & Testa, J. R. (1998). Clinical relevance of chromosome abnormalities in non-small cell lung cancer. Cancer Genetics and Cytogenetics, 102(1), 25-31. https://doi.org/10.1016/S0165-4608(97)00274-4

Clinical relevance of chromosome abnormalities in non-small cell lung cancer. / Feder, Madelyn; Siegfried, Jill M.; Balshem, Andrew; Litwin, Samuel; Keller, Steven M.; Liu, Zemin; Testa, Joseph R.

In: Cancer Genetics and Cytogenetics, Vol. 102, No. 1, 04.1998, p. 25-31.

Research output: Contribution to journalArticle

Feder, M, Siegfried, JM, Balshem, A, Litwin, S, Keller, SM, Liu, Z & Testa, JR 1998, 'Clinical relevance of chromosome abnormalities in non-small cell lung cancer', Cancer Genetics and Cytogenetics, vol. 102, no. 1, pp. 25-31. https://doi.org/10.1016/S0165-4608(97)00274-4
Feder, Madelyn ; Siegfried, Jill M. ; Balshem, Andrew ; Litwin, Samuel ; Keller, Steven M. ; Liu, Zemin ; Testa, Joseph R. / Clinical relevance of chromosome abnormalities in non-small cell lung cancer. In: Cancer Genetics and Cytogenetics. 1998 ; Vol. 102, No. 1. pp. 25-31.
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