Clinical prediction of cavotricuspid isthmus dependence in patients referred for catheter ablation of "typical" atrial flutter

Lars Lickfett, Hugh Calkins, Khurram Nasir, Timm Dickfeld, Zayd Eldadah, Vinod Jayam, Charles Leng, Gordon F. Tomaselli, Kevin Donahue, Henry Halperin, Berndt Lüderitz, Ronald Berger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Typical Atrial Flutter Prediction Introduction: Typical atrial flutter (AFL) can be cured by catheter ablation of the cavotricuspid isthmus (CTI). The surface electrocardiogram (ECG) is not always diagnostic of isthmus dependence of AFL. The aim of this study was to evaluate clinical parameters for the prediction of isthmus-dependent AFL. Methods and Results: Sixty consecutive adult patients without suspected atriotomy-related AFL, congenital heart disease, or previous AFL ablation, referred for catheter ablation of presumed typical AFL were studied. All patients had distinct flutter waves in the inferior leads, suggestive of CTI-dependent AFL, either on presentation to the electrophysiology (EP) lab or documented on prior ECG. Electrophysiology study was performed in the standard fashion. Patients who presented to the EP laboratory not in AFL underwent arrhythmia induction with a burst pacing protocol. A clinical history of persistent AFL (P = 0.0001) and existence of AFL on presentation to the EP laboratory (P = 0.0001) were strong predictors of CTI dependence. History of atrial fibrillation (P = 0.19), structural heart disease (P = 0.6), hypertension (P = 0.4), and previous cardiac surgery (P = 0.5), as well as the nature of AFL-related symptoms (P = 0.5), were not predictors of CTI-dependent AFL documented during EP study. Conclusion: In patients with ECG suggestive of typical AFL, the presence of persistent rather than paroxysmal AFL and presentation to the EP laboratory in AFL are strong predictors of CTI-dependent AFL. A paroxysmal pattern of AFL predicts noninducibility of CTI-dependent AFL during EP study. CTI ablation may therefore be less effective in these patients.

Original languageEnglish (US)
Pages (from-to)969-973
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

Fingerprint

Atrial Flutter
Catheter Ablation
Electrophysiology
Electrocardiography
Heart Diseases

Keywords

  • Atrial flutter
  • Cavotricuspid isthmus
  • Electrophysiology study
  • Paroxysmal
  • Persistent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Clinical prediction of cavotricuspid isthmus dependence in patients referred for catheter ablation of "typical" atrial flutter. / Lickfett, Lars; Calkins, Hugh; Nasir, Khurram; Dickfeld, Timm; Eldadah, Zayd; Jayam, Vinod; Leng, Charles; Tomaselli, Gordon F.; Donahue, Kevin; Halperin, Henry; Lüderitz, Berndt; Berger, Ronald.

In: Journal of Cardiovascular Electrophysiology, Vol. 16, No. 9, 01.09.2005, p. 969-973.

Research output: Contribution to journalArticle

Lickfett, L, Calkins, H, Nasir, K, Dickfeld, T, Eldadah, Z, Jayam, V, Leng, C, Tomaselli, GF, Donahue, K, Halperin, H, Lüderitz, B & Berger, R 2005, 'Clinical prediction of cavotricuspid isthmus dependence in patients referred for catheter ablation of "typical" atrial flutter', Journal of Cardiovascular Electrophysiology, vol. 16, no. 9, pp. 969-973. https://doi.org/10.1111/j.1540-8167.2005.50024.x
Lickfett, Lars ; Calkins, Hugh ; Nasir, Khurram ; Dickfeld, Timm ; Eldadah, Zayd ; Jayam, Vinod ; Leng, Charles ; Tomaselli, Gordon F. ; Donahue, Kevin ; Halperin, Henry ; Lüderitz, Berndt ; Berger, Ronald. / Clinical prediction of cavotricuspid isthmus dependence in patients referred for catheter ablation of "typical" atrial flutter. In: Journal of Cardiovascular Electrophysiology. 2005 ; Vol. 16, No. 9. pp. 969-973.
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abstract = "Typical Atrial Flutter Prediction Introduction: Typical atrial flutter (AFL) can be cured by catheter ablation of the cavotricuspid isthmus (CTI). The surface electrocardiogram (ECG) is not always diagnostic of isthmus dependence of AFL. The aim of this study was to evaluate clinical parameters for the prediction of isthmus-dependent AFL. Methods and Results: Sixty consecutive adult patients without suspected atriotomy-related AFL, congenital heart disease, or previous AFL ablation, referred for catheter ablation of presumed typical AFL were studied. All patients had distinct flutter waves in the inferior leads, suggestive of CTI-dependent AFL, either on presentation to the electrophysiology (EP) lab or documented on prior ECG. Electrophysiology study was performed in the standard fashion. Patients who presented to the EP laboratory not in AFL underwent arrhythmia induction with a burst pacing protocol. A clinical history of persistent AFL (P = 0.0001) and existence of AFL on presentation to the EP laboratory (P = 0.0001) were strong predictors of CTI dependence. History of atrial fibrillation (P = 0.19), structural heart disease (P = 0.6), hypertension (P = 0.4), and previous cardiac surgery (P = 0.5), as well as the nature of AFL-related symptoms (P = 0.5), were not predictors of CTI-dependent AFL documented during EP study. Conclusion: In patients with ECG suggestive of typical AFL, the presence of persistent rather than paroxysmal AFL and presentation to the EP laboratory in AFL are strong predictors of CTI-dependent AFL. A paroxysmal pattern of AFL predicts noninducibility of CTI-dependent AFL during EP study. CTI ablation may therefore be less effective in these patients.",
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AU - Nasir, Khurram

AU - Dickfeld, Timm

AU - Eldadah, Zayd

AU - Jayam, Vinod

AU - Leng, Charles

AU - Tomaselli, Gordon F.

AU - Donahue, Kevin

AU - Halperin, Henry

AU - Lüderitz, Berndt

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N2 - Typical Atrial Flutter Prediction Introduction: Typical atrial flutter (AFL) can be cured by catheter ablation of the cavotricuspid isthmus (CTI). The surface electrocardiogram (ECG) is not always diagnostic of isthmus dependence of AFL. The aim of this study was to evaluate clinical parameters for the prediction of isthmus-dependent AFL. Methods and Results: Sixty consecutive adult patients without suspected atriotomy-related AFL, congenital heart disease, or previous AFL ablation, referred for catheter ablation of presumed typical AFL were studied. All patients had distinct flutter waves in the inferior leads, suggestive of CTI-dependent AFL, either on presentation to the electrophysiology (EP) lab or documented on prior ECG. Electrophysiology study was performed in the standard fashion. Patients who presented to the EP laboratory not in AFL underwent arrhythmia induction with a burst pacing protocol. A clinical history of persistent AFL (P = 0.0001) and existence of AFL on presentation to the EP laboratory (P = 0.0001) were strong predictors of CTI dependence. History of atrial fibrillation (P = 0.19), structural heart disease (P = 0.6), hypertension (P = 0.4), and previous cardiac surgery (P = 0.5), as well as the nature of AFL-related symptoms (P = 0.5), were not predictors of CTI-dependent AFL documented during EP study. Conclusion: In patients with ECG suggestive of typical AFL, the presence of persistent rather than paroxysmal AFL and presentation to the EP laboratory in AFL are strong predictors of CTI-dependent AFL. A paroxysmal pattern of AFL predicts noninducibility of CTI-dependent AFL during EP study. CTI ablation may therefore be less effective in these patients.

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