Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices

Joann J. Kang, David C. Ritterband, Richard T. Atallah, Jeffrey M. Liebmann, John A. Seedor

Research output: Contribution to journalArticle

Abstract

Precis:In this retrospective case series of 85 eyes, 31.8% developed graft failure and graft survival was 50% at 3 years. The presence of an aqueous shunt has a significantly adverse effect on long-term graft survival.Purpose:To report visual outcomes and complications of Descemet stripping endothelial keratoplasty (DSEK) in eyes with glaucoma drainage devices (GDD).Materials and Methods:A retrospective chart review was conducted of 122 procedures of 85 eyes of 83 patients who underwent DSEK and had prior or concurrent GDD implantation. Mean follow-up was 36.5±31.4 months. Patients with postoperative follow-up of <3 months were excluded from analysis. Outcome measures examined included visual acuity, donor dislocation rate, intraocular pressure (IOP), and graft survival.Results:The mean logMAR vision improved to 1.07 postoperatively from 1.43 preoperatively, with 61% of eyes experiencing improved visual acuity. Graft dislocation occurred in 27 (31.8%) eyes and required repeat injection of air in the anterior chamber. Primary graft failure occurred in 2 (2.4%) eyes, whereas secondary graft failure occurred in 27 (31.8%) of eyes, with an average time of 24.3 months for development. Estimated survival rates at 1, 2, and 3 years were 89%, 78%, and 50%, respectively. Escalation of IOP occurred in 21 (24.7%) eyes postoperatively, where 14 eyes underwent medical therapy and 7 eyes required surgical intervention/laser for IOP control.Conclusions:DSEK after GDD is a viable alternative to treat endothelial dysfunction, with the majority of patients achieving visual improvement. However, aqueous shunt implantation has a significantly adverse effect on long-term graft survival and close follow-up is warranted.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalJournal of Glaucoma
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2019

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Descemet Stripping Endothelial Keratoplasty
Glaucoma
Drainage
Equipment and Supplies
Graft Survival
Glaucoma Drainage Implants
Intraocular Pressure
Transplants
Visual Acuity
Anterior Chamber
Lasers
Survival Rate

Keywords

  • DSEK
  • glaucoma
  • graft dislocation
  • graft failure

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices. / Kang, Joann J.; Ritterband, David C.; Atallah, Richard T.; Liebmann, Jeffrey M.; Seedor, John A.

In: Journal of Glaucoma, Vol. 28, No. 7, 01.07.2019, p. 601-605.

Research output: Contribution to journalArticle

Kang, Joann J. ; Ritterband, David C. ; Atallah, Richard T. ; Liebmann, Jeffrey M. ; Seedor, John A. / Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices. In: Journal of Glaucoma. 2019 ; Vol. 28, No. 7. pp. 601-605.
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