Clinical Implications and Management Strategies for Left Atrial Appendage Leaks

Anu Sahore, Domenico G. Della Rocca, Alisara Anannab, Sanghamitra Mohanty, Krishna Akella, Ghulam Murtaza, Chintan Trivedi, Carola Gianni, Qiong Chen, Mohamed Bassiouny, Ashkan Ahmadian-Tehrani, Bryan Macdonald, Amin Al-Ahmad, Nicola Tarantino, Donatello Cirone, Rodney P. Horton, Jorge Romero, Dhanunjaya Lakkireddy, Luigi Di Biase, Andrea Natale

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Left atrial appendage (LAA) is the dominant source of systemic thromboembolic (TE) events in patients with nonvalvular atrial fibrillation (AF). In patients with significant bleeding risk, various LAA exclusion strategies have been developed as an alternative to pharmacologic TE prophylaxis. Nevertheless, in a relatively small percentage of patients, incomplete LAA closure can be documented, either at the time of procedure or during follow-up. This persistent patency can potentially jeopardize an effective stroke prophylaxis. Hereby, we report an update on the current clinical implications of LAA leaks and how to manage them.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalCardiac Electrophysiology Clinics
Issue number1
StatePublished - Mar 2020


  • Amulet
  • Lariat
  • Leak
  • Left atrial appendage
  • Outcome
  • Stroke
  • Transient ischemic attach
  • Watchman

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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