Clinical Experience with the Subcutaneous Implantable Cardioverter-Defibrillator in Adults with Congenital Heart Disease

Jeremy P. Moore, Blandine Mondésert, Michael S. Lloyd, Stephen C. Cook, Ali N. Zaidi, Robert H. Pass, Anitha S. John, Frank A. Fish, Kevin M. Shannon, Jamil A. Aboulhosn, Paul Khairy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background - Sudden cardiac death is a major contributor to mortality for adults with congenital heart disease. The subcutaneous implantable cardioverter-defibrillator (ICD) has emerged as a novel tool for prevention of sudden cardiac death, but clinical performance data for adults with congenital heart disease are limited. Methods and Results - A retrospective study involving 7 centers over a 5-year period beginning in 2011 was performed. Twenty-one patients (median 33.9 years) were identified. The most common diagnosis was single ventricle physiology (52%), 9 palliated by Fontan operation and 2 by aortopulmonary shunts: d-transposition of the great arteries after Mustard/Senning (n=2), tetralogy of Fallot (n=2), aortic valve disease (n=2), and other biventricular surgery (n=4). A prior cardiac device had been implanted in 7 (33%). The ICD indication was primary prevention in 67% and secondary in 33% patients. The most common reason for subcutaneous ICD placement was limited transvenous access for ventricular lead placement (n=10) followed by intracardiac right-to-left shunt (n=5). Ventricular arrhythmia was induced in 17 (81%) and was converted with ≤80 Joules in all. There was one implant complication related to infection, not requiring device removal. Over a median follow-up of 14 months, 4 patients (21%) received inappropriate and 1 (5%) patient received appropriate shocks. There was one arrhythmic death related to asystole in a single ventricle patient. Conclusions - Subcutaneous ICD implantation is feasible for adults with congenital heart disease patients. Most candidates have single ventricle heart disease and limited transvenous options for ICD placement. Despite variable anatomy, this study demonstrates successful conversion of induced ventricular arrhythmia and reasonable rhythm discrimination during follow-up.

Original languageEnglish (US)
Article numbere004338
JournalCirculation: Arrhythmia and Electrophysiology
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Implantable Defibrillators
Heart Diseases
Sudden Cardiac Death
Cardiac Arrhythmias
Device Removal
Fontan Procedure
Aortic Diseases
Transposition of Great Vessels
Mustard Plant
Tetralogy of Fallot
Primary Prevention
Heart Arrest
Aortic Valve
Shock
Anatomy
Retrospective Studies
Equipment and Supplies
Mortality
Infection

Keywords

  • congenital heart disease
  • Fontan procedure
  • subcutaneous implantable cardioverter-defibrillator
  • sudden cardiac death
  • ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Clinical Experience with the Subcutaneous Implantable Cardioverter-Defibrillator in Adults with Congenital Heart Disease. / Moore, Jeremy P.; Mondésert, Blandine; Lloyd, Michael S.; Cook, Stephen C.; Zaidi, Ali N.; Pass, Robert H.; John, Anitha S.; Fish, Frank A.; Shannon, Kevin M.; Aboulhosn, Jamil A.; Khairy, Paul.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 9, No. 9, e004338, 01.09.2016.

Research output: Contribution to journalArticle

Moore, JP, Mondésert, B, Lloyd, MS, Cook, SC, Zaidi, AN, Pass, RH, John, AS, Fish, FA, Shannon, KM, Aboulhosn, JA & Khairy, P 2016, 'Clinical Experience with the Subcutaneous Implantable Cardioverter-Defibrillator in Adults with Congenital Heart Disease', Circulation: Arrhythmia and Electrophysiology, vol. 9, no. 9, e004338. https://doi.org/10.1161/CIRCEP.116.004338
Moore, Jeremy P. ; Mondésert, Blandine ; Lloyd, Michael S. ; Cook, Stephen C. ; Zaidi, Ali N. ; Pass, Robert H. ; John, Anitha S. ; Fish, Frank A. ; Shannon, Kevin M. ; Aboulhosn, Jamil A. ; Khairy, Paul. / Clinical Experience with the Subcutaneous Implantable Cardioverter-Defibrillator in Adults with Congenital Heart Disease. In: Circulation: Arrhythmia and Electrophysiology. 2016 ; Vol. 9, No. 9.
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abstract = "Background - Sudden cardiac death is a major contributor to mortality for adults with congenital heart disease. The subcutaneous implantable cardioverter-defibrillator (ICD) has emerged as a novel tool for prevention of sudden cardiac death, but clinical performance data for adults with congenital heart disease are limited. Methods and Results - A retrospective study involving 7 centers over a 5-year period beginning in 2011 was performed. Twenty-one patients (median 33.9 years) were identified. The most common diagnosis was single ventricle physiology (52{\%}), 9 palliated by Fontan operation and 2 by aortopulmonary shunts: d-transposition of the great arteries after Mustard/Senning (n=2), tetralogy of Fallot (n=2), aortic valve disease (n=2), and other biventricular surgery (n=4). A prior cardiac device had been implanted in 7 (33{\%}). The ICD indication was primary prevention in 67{\%} and secondary in 33{\%} patients. The most common reason for subcutaneous ICD placement was limited transvenous access for ventricular lead placement (n=10) followed by intracardiac right-to-left shunt (n=5). Ventricular arrhythmia was induced in 17 (81{\%}) and was converted with ≤80 Joules in all. There was one implant complication related to infection, not requiring device removal. Over a median follow-up of 14 months, 4 patients (21{\%}) received inappropriate and 1 (5{\%}) patient received appropriate shocks. There was one arrhythmic death related to asystole in a single ventricle patient. Conclusions - Subcutaneous ICD implantation is feasible for adults with congenital heart disease patients. Most candidates have single ventricle heart disease and limited transvenous options for ICD placement. Despite variable anatomy, this study demonstrates successful conversion of induced ventricular arrhythmia and reasonable rhythm discrimination during follow-up.",
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AU - Cook, Stephen C.

AU - Zaidi, Ali N.

AU - Pass, Robert H.

AU - John, Anitha S.

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AB - Background - Sudden cardiac death is a major contributor to mortality for adults with congenital heart disease. The subcutaneous implantable cardioverter-defibrillator (ICD) has emerged as a novel tool for prevention of sudden cardiac death, but clinical performance data for adults with congenital heart disease are limited. Methods and Results - A retrospective study involving 7 centers over a 5-year period beginning in 2011 was performed. Twenty-one patients (median 33.9 years) were identified. The most common diagnosis was single ventricle physiology (52%), 9 palliated by Fontan operation and 2 by aortopulmonary shunts: d-transposition of the great arteries after Mustard/Senning (n=2), tetralogy of Fallot (n=2), aortic valve disease (n=2), and other biventricular surgery (n=4). A prior cardiac device had been implanted in 7 (33%). The ICD indication was primary prevention in 67% and secondary in 33% patients. The most common reason for subcutaneous ICD placement was limited transvenous access for ventricular lead placement (n=10) followed by intracardiac right-to-left shunt (n=5). Ventricular arrhythmia was induced in 17 (81%) and was converted with ≤80 Joules in all. There was one implant complication related to infection, not requiring device removal. Over a median follow-up of 14 months, 4 patients (21%) received inappropriate and 1 (5%) patient received appropriate shocks. There was one arrhythmic death related to asystole in a single ventricle patient. Conclusions - Subcutaneous ICD implantation is feasible for adults with congenital heart disease patients. Most candidates have single ventricle heart disease and limited transvenous options for ICD placement. Despite variable anatomy, this study demonstrates successful conversion of induced ventricular arrhythmia and reasonable rhythm discrimination during follow-up.

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