Clinical determinants of a positive visual inspection after treatment with acetic acid for cervical cancer screening

Philip E. Castle, Y. L. Qiao, F. H. Zhao, W. Chen, M. Valdez, X. Zhang, L. N. Kang, P. Bansil, P. Paul, P. Bai, R. Peck, J. Li, F. Chen, J. Jeronimo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective To examine the determinants of a positive visual inspection after acetic acid (VIA), including the relationship of testing positive for high-risk human papillomavirus (HR-HPV), which is the necessary cause of cervical cancer. Design A prospective cohort study. Setting Three clinical sites in rural China. Population A total of 7541 women aged 25-65 years. Methods All women underwent VIA, DNA testing, by two DNA tests performed on both clinician- and self-collected specimens, and HPV E6 oncoprotein testing. Those positive by any test underwent colposcopy and four-quadrant biopsy evaluation. A random sample of women with negative screening results also underwent colposcopy and, if colposcopic abnormalities were observed, four-quadrant biopsy evaluation was performed. Women diagnosed with cervical intraepithelial neoplasia grade 2 (CIN2), or more severe grades (CIN2 +), underwent treatment. Main outcome measure Testing positive for VIA. Results Overall, 7.6% (95% confidence interval, 95% CI, 7.0-8.2%) had a positive VIA. Women who tested positive for HPV were more likely to have a positive VIA than women who tested negative for HPV (15.0%, 95% CI 12.9-17.2% versus 6.3%, 95% CI 5.7-6.9%; P < 0.001). Older women were less likely to have a positive VIA (Ptrend < 0.001), including women with CIN2 + (Ptrend < 0.001). A logistic regression model demonstrated that diagnosis (CIN2 + versus <CIN2; odds ratio, OR, 32; 95% CI 11-100), testing HPV positive with a higher viral load (highest versus lowest; OR 4.3; 95% CI 2.5-7.4), and age (51 years and older versus <38 years; OR 0.22; 95% CI 0.17-0.30) were independent determinants of having a positive VIA. VIA was more likely to be positive for women with CIN2 + having an abnormal colposcopic impression versus women with CIN2 + regardless of colposcopic impression (71.4 versus 47.2%). Conclusions The age of the population and method of disease ascertainment should be considered in the interpretation of any VIA performance.

Original languageEnglish (US)
Pages (from-to)739-746
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume121
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

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Early Detection of Cancer
Uterine Cervical Neoplasms
Acetic Acid
Cervical Intraepithelial Neoplasia
Therapeutics
Colposcopy
Logistic Models
Biopsy
Oncogene Proteins
DNA
Viral Load
Population
China
Cohort Studies
Odds Ratio
Outcome Assessment (Health Care)
Prospective Studies
Confidence Intervals

Keywords

  • Cervical cancer screening
  • cervical intraepithelial neoplasia
  • human papillomavirus
  • visual inspection after acetic acid

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Clinical determinants of a positive visual inspection after treatment with acetic acid for cervical cancer screening. / Castle, Philip E.; Qiao, Y. L.; Zhao, F. H.; Chen, W.; Valdez, M.; Zhang, X.; Kang, L. N.; Bansil, P.; Paul, P.; Bai, P.; Peck, R.; Li, J.; Chen, F.; Jeronimo, J.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 121, No. 6, 2014, p. 739-746.

Research output: Contribution to journalArticle

Castle, PE, Qiao, YL, Zhao, FH, Chen, W, Valdez, M, Zhang, X, Kang, LN, Bansil, P, Paul, P, Bai, P, Peck, R, Li, J, Chen, F & Jeronimo, J 2014, 'Clinical determinants of a positive visual inspection after treatment with acetic acid for cervical cancer screening', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 121, no. 6, pp. 739-746. https://doi.org/10.1111/1471-0528.12646
Castle, Philip E. ; Qiao, Y. L. ; Zhao, F. H. ; Chen, W. ; Valdez, M. ; Zhang, X. ; Kang, L. N. ; Bansil, P. ; Paul, P. ; Bai, P. ; Peck, R. ; Li, J. ; Chen, F. ; Jeronimo, J. / Clinical determinants of a positive visual inspection after treatment with acetic acid for cervical cancer screening. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2014 ; Vol. 121, No. 6. pp. 739-746.
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abstract = "Objective To examine the determinants of a positive visual inspection after acetic acid (VIA), including the relationship of testing positive for high-risk human papillomavirus (HR-HPV), which is the necessary cause of cervical cancer. Design A prospective cohort study. Setting Three clinical sites in rural China. Population A total of 7541 women aged 25-65 years. Methods All women underwent VIA, DNA testing, by two DNA tests performed on both clinician- and self-collected specimens, and HPV E6 oncoprotein testing. Those positive by any test underwent colposcopy and four-quadrant biopsy evaluation. A random sample of women with negative screening results also underwent colposcopy and, if colposcopic abnormalities were observed, four-quadrant biopsy evaluation was performed. Women diagnosed with cervical intraepithelial neoplasia grade 2 (CIN2), or more severe grades (CIN2 +), underwent treatment. Main outcome measure Testing positive for VIA. Results Overall, 7.6{\%} (95{\%} confidence interval, 95{\%} CI, 7.0-8.2{\%}) had a positive VIA. Women who tested positive for HPV were more likely to have a positive VIA than women who tested negative for HPV (15.0{\%}, 95{\%} CI 12.9-17.2{\%} versus 6.3{\%}, 95{\%} CI 5.7-6.9{\%}; P < 0.001). Older women were less likely to have a positive VIA (Ptrend < 0.001), including women with CIN2 + (Ptrend < 0.001). A logistic regression model demonstrated that diagnosis (CIN2 + versus <CIN2; odds ratio, OR, 32; 95{\%} CI 11-100), testing HPV positive with a higher viral load (highest versus lowest; OR 4.3; 95{\%} CI 2.5-7.4), and age (51 years and older versus <38 years; OR 0.22; 95{\%} CI 0.17-0.30) were independent determinants of having a positive VIA. VIA was more likely to be positive for women with CIN2 + having an abnormal colposcopic impression versus women with CIN2 + regardless of colposcopic impression (71.4 versus 47.2{\%}). Conclusions The age of the population and method of disease ascertainment should be considered in the interpretation of any VIA performance.",
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T1 - Clinical determinants of a positive visual inspection after treatment with acetic acid for cervical cancer screening

AU - Castle, Philip E.

AU - Qiao, Y. L.

AU - Zhao, F. H.

AU - Chen, W.

AU - Valdez, M.

AU - Zhang, X.

AU - Kang, L. N.

AU - Bansil, P.

AU - Paul, P.

AU - Bai, P.

AU - Peck, R.

AU - Li, J.

AU - Chen, F.

AU - Jeronimo, J.

PY - 2014

Y1 - 2014

N2 - Objective To examine the determinants of a positive visual inspection after acetic acid (VIA), including the relationship of testing positive for high-risk human papillomavirus (HR-HPV), which is the necessary cause of cervical cancer. Design A prospective cohort study. Setting Three clinical sites in rural China. Population A total of 7541 women aged 25-65 years. Methods All women underwent VIA, DNA testing, by two DNA tests performed on both clinician- and self-collected specimens, and HPV E6 oncoprotein testing. Those positive by any test underwent colposcopy and four-quadrant biopsy evaluation. A random sample of women with negative screening results also underwent colposcopy and, if colposcopic abnormalities were observed, four-quadrant biopsy evaluation was performed. Women diagnosed with cervical intraepithelial neoplasia grade 2 (CIN2), or more severe grades (CIN2 +), underwent treatment. Main outcome measure Testing positive for VIA. Results Overall, 7.6% (95% confidence interval, 95% CI, 7.0-8.2%) had a positive VIA. Women who tested positive for HPV were more likely to have a positive VIA than women who tested negative for HPV (15.0%, 95% CI 12.9-17.2% versus 6.3%, 95% CI 5.7-6.9%; P < 0.001). Older women were less likely to have a positive VIA (Ptrend < 0.001), including women with CIN2 + (Ptrend < 0.001). A logistic regression model demonstrated that diagnosis (CIN2 + versus <CIN2; odds ratio, OR, 32; 95% CI 11-100), testing HPV positive with a higher viral load (highest versus lowest; OR 4.3; 95% CI 2.5-7.4), and age (51 years and older versus <38 years; OR 0.22; 95% CI 0.17-0.30) were independent determinants of having a positive VIA. VIA was more likely to be positive for women with CIN2 + having an abnormal colposcopic impression versus women with CIN2 + regardless of colposcopic impression (71.4 versus 47.2%). Conclusions The age of the population and method of disease ascertainment should be considered in the interpretation of any VIA performance.

AB - Objective To examine the determinants of a positive visual inspection after acetic acid (VIA), including the relationship of testing positive for high-risk human papillomavirus (HR-HPV), which is the necessary cause of cervical cancer. Design A prospective cohort study. Setting Three clinical sites in rural China. Population A total of 7541 women aged 25-65 years. Methods All women underwent VIA, DNA testing, by two DNA tests performed on both clinician- and self-collected specimens, and HPV E6 oncoprotein testing. Those positive by any test underwent colposcopy and four-quadrant biopsy evaluation. A random sample of women with negative screening results also underwent colposcopy and, if colposcopic abnormalities were observed, four-quadrant biopsy evaluation was performed. Women diagnosed with cervical intraepithelial neoplasia grade 2 (CIN2), or more severe grades (CIN2 +), underwent treatment. Main outcome measure Testing positive for VIA. Results Overall, 7.6% (95% confidence interval, 95% CI, 7.0-8.2%) had a positive VIA. Women who tested positive for HPV were more likely to have a positive VIA than women who tested negative for HPV (15.0%, 95% CI 12.9-17.2% versus 6.3%, 95% CI 5.7-6.9%; P < 0.001). Older women were less likely to have a positive VIA (Ptrend < 0.001), including women with CIN2 + (Ptrend < 0.001). A logistic regression model demonstrated that diagnosis (CIN2 + versus <CIN2; odds ratio, OR, 32; 95% CI 11-100), testing HPV positive with a higher viral load (highest versus lowest; OR 4.3; 95% CI 2.5-7.4), and age (51 years and older versus <38 years; OR 0.22; 95% CI 0.17-0.30) were independent determinants of having a positive VIA. VIA was more likely to be positive for women with CIN2 + having an abnormal colposcopic impression versus women with CIN2 + regardless of colposcopic impression (71.4 versus 47.2%). Conclusions The age of the population and method of disease ascertainment should be considered in the interpretation of any VIA performance.

KW - Cervical cancer screening

KW - cervical intraepithelial neoplasia

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KW - visual inspection after acetic acid

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