Clinical Correlates of Alzheimer's Disease With and Without Silent Radiographic Abnormalities

Karen Marder, Marcus Richards, Jacqueline A. Bello, Karen Bell, Mary Sano, Lisa Miller, Marshal Folstein, Marilyn Albert, Yaakov Stern

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

To determine whether patients with Alzheimer's disease (AD) who do not have historical or clinical evidence of stroke but who do have computed tomographic or magnetic resonance imaging evidence of noncortical lesions smaller than 2 cm or periventricular “caps” differ from other patients with AD. The computed tomographic or magnetic resonance imaging scans of 158 patients meeting criteria of the National Institute of Neurological Disorders and Stroke—Alzheimer's Disease and Related Disorders Association for probable AD were reviewed by one neuroradiologist. Two measures of disease severity—the Modified Mini-Mental State examination and the Blessed Dementia Rating Scale (Part I)—were subjected to two-way analysis of variance with scan type (computed tomography or magnetic resonance imaging) and lesion number as between-group factors and age and disease duration as covariates. No relationship was seen between lesion number or periventricular caps and disease severity. In this cross-sectional analysis using these clinical measures, patients with AD who have well-defined radiographic abnormalities cannot be differentiated from patients with AD who do not have them.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalArchives of Neurology
Volume52
Issue number2
DOIs
StatePublished - 1995

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Alzheimer Disease
Magnetic Resonance Imaging
Age Factors
Nervous System Diseases
Dementia
Analysis of Variance
Age Groups
Cross-Sectional Studies
Stroke
Tomography
Alzheimer's Disease
Lesion

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Clinical Correlates of Alzheimer's Disease With and Without Silent Radiographic Abnormalities. / Marder, Karen; Richards, Marcus; Bello, Jacqueline A.; Bell, Karen; Sano, Mary; Miller, Lisa; Folstein, Marshal; Albert, Marilyn; Stern, Yaakov.

In: Archives of Neurology, Vol. 52, No. 2, 1995, p. 146-151.

Research output: Contribution to journalArticle

Marder, K, Richards, M, Bello, JA, Bell, K, Sano, M, Miller, L, Folstein, M, Albert, M & Stern, Y 1995, 'Clinical Correlates of Alzheimer's Disease With and Without Silent Radiographic Abnormalities', Archives of Neurology, vol. 52, no. 2, pp. 146-151. https://doi.org/10.1001/archneur.1995.00540260050015
Marder, Karen ; Richards, Marcus ; Bello, Jacqueline A. ; Bell, Karen ; Sano, Mary ; Miller, Lisa ; Folstein, Marshal ; Albert, Marilyn ; Stern, Yaakov. / Clinical Correlates of Alzheimer's Disease With and Without Silent Radiographic Abnormalities. In: Archives of Neurology. 1995 ; Vol. 52, No. 2. pp. 146-151.
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