Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day

R. H. Perlis, J. Alpert, A. A. Nierenberg, D. Mischoulon, A. Yeung, J. F. Rosenbaum, M. Fava

Research output: Contribution to journalArticle

26 Scopus citations


Objective: Patients with major depressive disorder often show only partial or no response to antidepressants, necessitating next-step interventions such as dose increase or augmentation. Factors moderating response to these next-step interventions are not well-studied. Method: In this randomized, double-blind investigation of next-step treatments in 101 outpatients who failed to respond to fluoxetine 20 mg for 8 weeks, the impact of depressive course and sociodemographic factors on likelihood of treatment response following dose increase or lithium or desipramine augmentation was examined. Results: After controlling for depression severity at baseline, current marriage and earlier onset of depression were associated with greater likelihood of response in a logistic regression. Intervention strategy was not predictive of response. Conclusion: Marital status and earlier onset of depression may be clinically useful in predicting outcome following any next-step intervention for treatment resistance, rather than with particular strategies.

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalActa Psychiatrica Scandinavica
Issue number6
Publication statusPublished - Dec 1 2003
Externally publishedYes



  • Antidepressive agents
  • Depression
  • Desipramine
  • Fluoxetine
  • Lithium carbonate

ASJC Scopus subject areas

  • Psychiatry and Mental health

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