Abstract
Objective: Patients with major depressive disorder often show only partial or no response to antidepressants, necessitating next-step interventions such as dose increase or augmentation. Factors moderating response to these next-step interventions are not well-studied. Method: In this randomized, double-blind investigation of next-step treatments in 101 outpatients who failed to respond to fluoxetine 20 mg for 8 weeks, the impact of depressive course and sociodemographic factors on likelihood of treatment response following dose increase or lithium or desipramine augmentation was examined. Results: After controlling for depression severity at baseline, current marriage and earlier onset of depression were associated with greater likelihood of response in a logistic regression. Intervention strategy was not predictive of response. Conclusion: Marital status and earlier onset of depression may be clinically useful in predicting outcome following any next-step intervention for treatment resistance, rather than with particular strategies.
Original language | English (US) |
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Pages (from-to) | 432-438 |
Number of pages | 7 |
Journal | Acta Psychiatrica Scandinavica |
Volume | 108 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2003 |
Externally published | Yes |
Keywords
- Antidepressive agents
- Depression
- Desipramine
- Fluoxetine
- Lithium carbonate
ASJC Scopus subject areas
- Psychiatry and Mental health