Clinical and Immunologic Effects of Lipid-Based Parenteral Nutrition in AIDS

Pierre Singer; Arye Rubinstein; Jeffrey Askanazi; Terry Calvelli; Tadd Lazarus; Olli Kirvelä; David P. Katz

doi:10.1177/0148607192016002165

Clinical and Immunologic Effects of Lipid-Based Parenteral Nutrition in AIDS

Pierre Singer, Arye Rubinstein, Jeffrey Askanazi, Terry Calvelli, Tadd Lazarus, Olli Kirvelä, David P. Katz

Pediatrics

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The effect of lipid-based parenteral nutrition was assessed in eight patients with AIDS and weight loss of 10% or greater. All patients received home parenteral nutrition consisting of a lipid-based system with 50% of nonprotein calories given as fat. Measurements were made of body weight, serum albumin, and immune function as assessed by mitogen responses, P24 antigen levels and T-cell counts. Over a period of 2 months, weight gain and improved well-being were noted in all patients. An improved in vitro lymphocyte mitogenic response to phytohemagglutinin and to concanavalin A was also noted. No change in T-cell subsets was observed. Viral cultures and P24 serum levels also remained unchanged. Lipid-based parenteral nutrition is safe and probably efficacious in AIDS. (Journal of Parenteral and Enteral Nutrition 16:165-167, 1992).

Original language	English (US)
Pages (from-to)	165-167
Number of pages	3
Journal	Journal of Parenteral and Enteral Nutrition
Volume	16
Issue number	2
DOIs	https://doi.org/10.1177/0148607192016002165
State	Published - Mar 1992

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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title = "Clinical and Immunologic Effects of Lipid-Based Parenteral Nutrition in AIDS",

abstract = "The effect of lipid-based parenteral nutrition was assessed in eight patients with AIDS and weight loss of 10% or greater. All patients received home parenteral nutrition consisting of a lipid-based system with 50% of nonprotein calories given as fat. Measurements were made of body weight, serum albumin, and immune function as assessed by mitogen responses, P24 antigen levels and T-cell counts. Over a period of 2 months, weight gain and improved well-being were noted in all patients. An improved in vitro lymphocyte mitogenic response to phytohemagglutinin and to concanavalin A was also noted. No change in T-cell subsets was observed. Viral cultures and P24 serum levels also remained unchanged. Lipid-based parenteral nutrition is safe and probably efficacious in AIDS. (Journal of Parenteral and Enteral Nutrition 16:165-167, 1992).",

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AU - Singer, Pierre

AU - Rubinstein, Arye

AU - Askanazi, Jeffrey

AU - Calvelli, Terry

AU - Lazarus, Tadd

AU - Kirvelä, Olli

AU - Katz, David P.

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AB - The effect of lipid-based parenteral nutrition was assessed in eight patients with AIDS and weight loss of 10% or greater. All patients received home parenteral nutrition consisting of a lipid-based system with 50% of nonprotein calories given as fat. Measurements were made of body weight, serum albumin, and immune function as assessed by mitogen responses, P24 antigen levels and T-cell counts. Over a period of 2 months, weight gain and improved well-being were noted in all patients. An improved in vitro lymphocyte mitogenic response to phytohemagglutinin and to concanavalin A was also noted. No change in T-cell subsets was observed. Viral cultures and P24 serum levels also remained unchanged. Lipid-based parenteral nutrition is safe and probably efficacious in AIDS. (Journal of Parenteral and Enteral Nutrition 16:165-167, 1992).

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